Alzheimer’s disease (AD) is a common, weakening neurodegenerative disease that affects about 10 % of people over 65 years of age and one -third of people aged 85 or older. In addition to environmental factors, genes have a strong effect on whether or not a person develops advertising during their lifetime. Through the sequence of DNA genome from large groups of healthy people and people with ad, some naturally appearing minor DNA changes, known as genetic variants, were found more common in patients with AD than in healthy people. As more and more of these AD -related variants, it is now possible to calculate the individual rating of a person’s polygonal risk (PRS), which means the possibility of developing ad, with high precision. Despite this progress, it is still largely unknown how genetic risk variants or combinations cause ad in individual patients and more specifically how risk variations affect the health and function of brain cells.
To deal with this, researchers in the United Kingdom Dementia Research at the University of Cardiff, the United Kingdom, have now set up the first large -scale stem cell bank from more than 100 people selected for extreme AD PRors, which had previously been identified with a sequence. Project results are published today Stem cells. About two thirds of the donors were diagnosed with AD and had relatively high PRS while one -third were cognitively healthy, people who corresponded to the age with low PRS. The blood cells of these individuals were genetically modified to convert them into induced multidimensional stem cells (IPSCs), which are immature cells capable of producing all cell types of the body. The new “IPSC platform for modeling the risk of Alzheimer’s disease” (IPMAR) will be available to researchers worldwide to facilitate studies on the impact of risk variations on IPSC cell models. Ultimately, the resource can be used to increase the understanding of the AD -related risk factors and can update the design of new, personalized treatments or prevention strategies.
Source:
Magazine report:
Maguire, E., et al. (2025). Modeling of Alzheimer’s common disease with high and low polygonal risk in human IPSC: a large -scale research resource. Stem cells. doi.org/10.1016/j.stemcr.2025.102570.
