Researchers at Philadelphia Children’s Hospital (CHOP) found that some lipids or fats, in foods that cause obesity, also cause inflammation of the asthma -like pneumon. The findings indicate that in addition to modifying dietary choices, some existing medicines could be redefined to help treat this type of asthma. Findings were published online today by magazine The translation medicine of science.
The study was caused by researchers who observe a correlation between childhood obesity and neutrophil asthma, a non -allergic asthma -activated asthma activated by microbial and bacterial proteins. Neutrophilic asthma is more difficult to treat than allergic asthma and more likely to be severe enough to send patients to the hospital, but the researchers did not understand the underlying causes of this type of asthma.
To study in more detail, the researchers focused on lung macrophages, which are specialized white blood cells that coordinate immune function during inflammation. While metabolic stress can alter macrophage function, the effects of specific dietary ingredients were unclear. In this study, the researchers found that some dietary fats, including those used in processed foods, form macrophages in the lungs during inflammatory response.
Before this study, many suspected that childhood obesity caused this form of asthma. However, we noticed neutrophil asthma to children who were not obese, so we suspected that there could be another mechanism. What we found in both preclinical work and studies in children was that diets containing certain long chain fatty acids can cause neutrophil asthma independent of obesity. “
David A. Hill, MD, PhD, Senior Study Author, Doctor Care, Department of Allergy and Immunology, Philadelphia Children’s Hospital
The researchers first investigated a high -fat diet in a preclinical animal model, where they found that lung macrophages collected a large -chain fatty acid fatty acid, often found in animal fats and processed foods. Specifically, dietary stearic acid aggravates the inflammation of the airways without causing obesity. In contrast, oleic acid, a long chain fatty acid monouns, suppressed inflammatory action. The researchers also found that the obstruction of IL-1B inflammatory cyatoquin or the inhibition of the protein IRE1⍺-both are at elevated levels in neutrophil asthma-protein by inflammation of the pulmonary with steaic acid. The study confirmed some of these preclinical findings in a group of obese asthma children.
“Asthma is one of the most common chronic diseases in children and may need different treatments depending on the hypothesis of asthma, said co-author of the study Lisa Young, MD, the head of the division of the pulmonary and medical sleep in the child. and indicate that targeted dietary modifications can help prevent this type of asthma. “
This study was supported by the grants of the National Institute of Health K08 DK116668, R01 HL162715, 5T32 DK007314-43, K24HL143281, American College of Allergy, Asthma and Immunology Junior Facany Grant, the Children’s Hospital.
Source:
Magazine report:
McCright, sj, et al. (2025) Dietary saturated fatty acids promote the activation of the inflammatory of myeloid cells of the lungs and the IL-1B of inflammation in mice and humans. The translation medicine of science. doi.org/10.1126/scitranslmed.adp5653
