Melanoma is a rapid skin cancer characterized by a high mortality rate after metastasis. Local chemotherapy could be seen as a therapeutic approach only at stage 0 of evolution (in situ melanoma) and in the postoperative phase after surgical removal of suspicion of skin lesions. To this end, drugs such as imiquimod, 5-fthororacil, daccarbazine and doxorubicin have been tested and have positive results. Recently, metal nanoparticles as separate therapeutic units or medicines have also fallen into research.
Silver nanoparticles (AGNPs), in particular, are widely recognized as multifunctional tools in nanomedics, drug tradition and therapeutic. They are involved in antimicrobial and anti-sound properties of broad spectrum, but their pharmacological effects are in close bond with the so-called “superficial functionality”. For example, negatively charged and spherical particles prove less toxic than positively charged particles, especially irregularly shaped (eg rods, cables, etc.). Still, because of this, the former are less powerful anti -cancer factors.
Modern pharmaceutical development is largely based on environmentally friendly technologies (often referred to as “green” technologies) that avoid the use of toxic solvents and reagents. This study has implemented such a method based on Camellia Sinensis as a natural silver ion reducer. In order to achieve enhanced antimicrobial and anti-Angi activity, the AGNPs were thus obtained further with chlorhexidine (CX+)-an antimicrobial factor of broad spectrum and a cationic surface. Indeed, the AGNP-CX+ complexes have shown extremely increased antimicrobial properties, about 18 times stronger anti-melanoma activity and 3 times better volume selectivity than non-functional agnps.
The most valuable result of this new study published in the magazine PharmaciesIt was the creation of an original adhesive patch as a local dosage for the AGNP-CX+complex. The polymers used, hydroxypropilo methylcellulose and eudragit® The RS has shown a lack of negative interference in the opposition to the active agent, but also ensured twice as much more activity and even better selectivity than tumor cells.
