Inhalation of agricultural dust can create significant risks to intestinal health for animal agriculture workers, a University of California, Riverside, found a study.
Led by Declan McCole, Professor of Biomedical Sciences at the UCR Medical School, the study is expanding to previous findings that pig farm dust causes inflammation of the airways. Researchers now report on Newspaper of applied toxicology That the inhalation of this dust also changes the gut germicide and prevents intestinal function, including increased “intestinal leakage” or intestinal permeability. The intestine leak is associated with a number of chronic diseases, including inflammatory bowel disease, celiac disease and type 1 diabetes.
“The pig’s dusting exhibition, which contains high levels of bacteria and endotoxins, has caused both the inflammation of the airways and increased passing of bacterial products in the mouse models,” said former author of Meli’s Crawford, formerly the former post -post. “But what is particularly impressive is the impact we noticed on the microbial and bowel metabolism.”
Researchers expose mice endorine to the pig dust extract for three weeks. Mice showed a significant decline in beneficial bacterial species, including Akkermansia Muciniphila, Clostridium sp. ASF356 and Lachnospiraceae bacterium.
The research team also found reduced levels of critical compounds in the intestine of mice, such as riboflavin, nicotinic acid, inosin and leucine – key players in energy metabolism, immune regulation and intestinal barrier maintenance.
While most research has focused on the respiratory effects of farm dust, our findings clearly show that inhaled pollutants can have systematic consequences. This study emphasizes the importance of examining the intestinal lung axis in evaluating the health risks of bioferozole exposure to agriculture. “
Declan McCole, Professor of Biomedical Sciences, UCR Medical School
The study is based on increasing evidence that pollution by concentrated animal power supplies can affect multiple organ systems.
“Agricultural dust is rich in fine particles and resistant bacteria, with a complex threat to farmers’ health,” McCole said. “The previous project has shown us that the inhaled pig dust extract leads to neutrophil lung inflammation. We now show the connection to intestinal barrier malfunction and microbial imbalances, underlining the need for improved workplace protection.
The study was supported by grants by National Institutes of Health. University of California, Davis-Western Agriculture and Security Center. and the Program of Presidential Postdoctoral Scholarships of the University of California. Crawford is now an assistant professor at the Animal Science Department at Rutgers University in New Jersey.
The title of the research document is “the respiratory exposure to the agricultural dust extract changes intestinal species and basic metabolites in mice”.
Source:
Magazine report:
Crawford, MS, et al. (2025). The respiratory exposure to the agricultural dust extract changes the bowel systems and the basic metabolites in mice. Newspaper of applied toxicology. doi.org/10.1002/jat.4808.
