Common vegetable oils accelerate skin regeneration

Laboratory tests reveal natural oils to accelerate skin repair and which slow down, as well as the amazing combinations of fatty acids behind the two results.

Study: Influence of vegetable oils and their ingredients in vitro human keratinocytes and proliferation and migration fibroblasts. Credit Picture: Natalyabond/Shutterstock.com

Researchers at the University of Ljubljana, Slovenia, explored the effect of selected vegetable oils and their voters on the growth and migration of skin cells. Their study, which is published in Scientific reportsIt supports the role of vegetable oils in increasing the regeneration of skin cells.

Background

The skin is the largest human organ that acts as a protective obstacle from foreign invaders, such as pathogens, chemicals and radiation. Keratinocytes and fibroblasts are the main types of skin cells that play a central role in repair and regeneration of the skin during the inflammatory phase.

Vegetable oils used in therapeutic and cosmetic products are able to cure injured or damaged skin. Triglycerides, including saturated and unsaturated fatty acids, are the main ingredients of vegetable oils (99%) and are known to have a series of beneficial effects, including antimicrobial, anti -inflammatory, antioxidants and active effects.

Vegetable oils contain a small amount (1%) of non -reactive compounds such as phytosterols, phenolic compounds, squalene, carotene and vitamins, which also have antimicrobial, antioxidant and anti -inflammatory effects.

Evidence shows that microbial lipases in the skins hydrolyte triglycerides to release free fatty acids. While some of these fatty acids, such as linoleic acid, are known to protect the integrity of the skin, others, such as oleic acid, are known for their blocked skin clogged.

The normal ratio of oleic acid to linoleic acid on the outer layer of the skin is 3: 1. Any imbalance or deficiency in the lipid profile of the skin is known to cause excessive dryness or flower of the skin with related skin diseases. However, there is a shortage of data on specific proportions of free fatty acids that would help predict if a particular vegetable oil will positively or negatively affect skin cells.

In the present study, the researchers investigated the effects of selected vegetable oils and their ingredients on the development and migration of fibroblasts and keratinocytes, focusing on the ingredient of triglycerides and non -reactionary compounds.

Researchers cultivated fibroblasts and keratinocytes in the laboratory and examined the effects of coconut, olive, Linden, poppy, pomegranate, daisies and linen on cell growth and healing of wounds (cell migration).

Basic findings

The findings of the study revealed that most of the tested vegetable oils mildly, but significantly increased the growth of fibroblasts and keratinocytes, in addition to pomegranate oil and mainstream acid (Punic acid), which significantly inhibit the growth of skin cells. Both coconut and olive oil did not show a significant effect on the growth of skin cells.

Vegetable oils with a high content of basic fatty acids, including linoleic and α-linolenic acid, had the most intense positive effect on cell growth. However, α-linolenic acid showed a two-phase effect, strongly inhibiting the proliferation of both keratinocytes and fibroblasts at higher concentrations (0.01 mg/100 µm) and 48 and 72 hours, while enhancing growth at lower concentrations (0.005 mg/100 mg/100 mg).

After 48 or 72 hours, most effects that enhance oil proliferation such as poppy, Linden, Lintseed and Marigold were observed at 0.15%or 0.1%, while lower concentrations (0.01%) did not generally show significant activity.

Individual fatty acids found in vegetable oils have shown a variety of effects, with some (lauric acid and myrrhist acid) increasing the growth of skin cells and in some (palmitic acid) constantly inhibiting the growth of fibroblasts and keratinocytes. Given the importance of oleic acid in the ratio of linoleic acid in health and skin disease, the study examined the effect of three different proportions (1: 3, 1: 1: 1 and 3: 1) on the development of skin cells.

The findings have collected collectively that the proportion of these two fatty acids is not vital to regulating the growth of skin cells. Instead, there seems to be a synergistic interaction between oleic acid and linoleic acid, emphasizing the importance of these two ingredients that will exist simultaneously in a vegetable oil or a final skin product. However, at higher concentrations (0.01 mg/100 ml) and after 72 hours, all three proportions significantly inhibit the growth of fibroblasts, even when they enhance the proliferation of keratinocytes, emphasizing the effects of cells and dose.

None of the proven vegetable oils showed significant positive or negative effects on the immigration of skin cells and no significant effect on cell morphology was observed. On the contrary, sterleric acid and oleic acid caused a significant decrease in immigration of skin cells. Linoleic acid also caused visible cell accumulation and locally increased density without slowing the vacuum closure. This phenomenon, which is shared with oily acid and its mixtures, may indicate altered cellular organization during healing.

In particular, the study found that oleic acid and linoleic acid individually or in combination, induced cell formation and increased cell density.

Importance

The findings of the study emphasize the importance of vegetable oils and their ingredients in enhancing skin regeneration and supporting their application in therapeutic and cosmetic skin care compositions.

According to the findings, the biological activity of these oils depends mainly on the synthesis of triglycerides fatty acids. Complex interactions between these fatty acids affect the effect of vegetable oils on the growth of skin cells, emphasizing the importance of understanding the precise chemical composition of vegetable oils. The study also found that the not fragmented fractions of certain oils, such as coconut and olive, could enhance the growth of fibroblasts or keratinocytes in specific doses. In contrast, fractions by Linden and Marigold sometimes inhibit the proliferation of fibroblasts, emphasizing the complexity of these secondary ingredients.

Non-reactionary compounds, although only ~ 1% of these oils, also showed complex roles, with some (such as beta-carotene and β-cithosterol) that promote the proliferation of keratinocytes and others (including pherulic acid and squadrite) in parallel with fatty acids.

The study used laboratory cultivated skin cells for experimental purposes. These cultivation models do not have the complexity of the normal skin environment, including the presence of immune cells, blood circulation and barrier function. These factors emphasize the need to validate the findings of the study in animal and human studies and to evaluate the safety profile and the effectiveness in real world conditions.

In addition, the study used primary skin fibroblasts from a single donor to ensure experimental consistency. Given this restriction, researchers advise that future studies should include many donors to evaluate the reproducibility and generality of the findings.

Download your PDF copy now!