A new research document was published in Aging (Aging) On January 3, 2025, in Volume 17, issue 1, entitled “Designation of DNA Methylation Clock algorithms applied to different types of tissue”.
Researchers Mark Richardson, Courtney Brandt, Niyati Jain, James L. Li, Kathryn Demanelis, Farzana Jasmine, Muhammad G. Kibriya, Lin Tong and Brandon L. DNA. Their study found that while the DNA methylation watches are commonly used “they work well for blood samples, it may be less reliable for other tissues such as lungs, colon and kidneys.
DNA methylation watches are widely used in research on forensic science, epigenetic and longevity to assess a person’s biological age based on chemical changes in DNA. These epigenetic watches help scientists predict age -related diseases and evaluate how lifestyle factors such as smoking, aging of the impact. Most were initially developed using blood samples and their effectiveness in other tissues remains unclear. This study examined eight different DNA methylation watches in nine types of human tissue, including lungs, prostate, ovarian, skeletal muscle and kidney. The researchers analyzed data from 973 tissue specimens collected through the genotype expression (GTEX).
Their analysis revealed significant differences in the estimates of biological age in all tissues. While blood samples provided the most reliable results, other tissues showed remarkable variations. For example, the tissues of the testicles and ovaries appeared younger than the expected, while the lung and colon tissues appeared larger.
“These differences between tissue types were more apparent for watches trained using DNAM only from blood (eg hannum). for anticipation of tissue age ”.
These findings indicate that aging may not occur at the same rate in each organ and that standard DNA methylation watches may not always give accurate biological estimates other than blood samples. The authors indicate that new epigenetic watches may be needed to improve the prediction of biological age. Creating clocks related to the tissue could also improve medical diagnosis, age -related disease prevention and health monitoring.
Researchers emphasize that larger studies are needed with more data methylation data data to improve these aging watches. By improving these tools, scientists can better understand how aging affects different organs and develops more reliable methods for measuring biological age. These developments could lead to better predictions for age -related diseases and new strategies for healthy aging.
Source:
Magazine report:
Richardson, M., et al. (2025). Designation of DNA methylation clock algorithms applied to different types of tissues. Aging. doi.org/10.18632/aging.206182.
