Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

AI converts sights for visual impairments

June 9, 2025

30 minutes Kettlebell Core Workouts to strengthen your abdomen

June 9, 2025

Semaglutide for Weight Loss – Summer Safety and Side Effects Guide

June 9, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    AI converts sights for visual impairments

    June 9, 2025

    AI model detects brain tumors with high precision using epigenetic fingerprints

    June 8, 2025

    The new study warns long -term risks from germ transplants

    June 8, 2025

    Self-collection tests could be a solution to increase access to cervical cancer control

    June 7, 2025

    Preeclampsia associated with long -term brave disbelief and worsening the effects of stroke

    June 7, 2025
  • Mental Health

    Heart attack or panic attack? Why do young people call ambulances for non -managed stress

    June 7, 2025

    My journey, my development, my truth – uninterrupted

    June 6, 2025

    Why I am fighting for mental health change

    June 3, 2025

    Girls with painful periods are twice as high as their peers to have symptoms of anxiety or depression

    June 2, 2025

    Does psychiatric drug kill creativity? Rejecting Van Gogh’s myth

    May 29, 2025
  • Men’s Health

    30 minutes Kettlebell Core Workouts to strengthen your abdomen

    June 9, 2025

    Scientists identify genetic indications that connect air pollution to neurodegeneration

    June 7, 2025

    Do you want a stronger back? This Powerlifter’s secret weapon is a secret weapon

    June 7, 2025

    Chains, bands and greater profits: Guide to deal with resistance

    June 6, 2025

    Phil Stutz, True Magic & Healing Mankind: Useful tools for today’s World – Part 2: Universe 1 and Universe 2

    June 6, 2025
  • Women’s Health

    Making the connection between collagen and recovery from exercise

    June 8, 2025

    Alice Connors for purpose and progress

    June 4, 2025

    8 teenagers of vitamins must actually get

    June 4, 2025

    Reasons for frequent urination

    June 3, 2025

    Life with myalgian encephalomyelitis/chronic fatigue syndrome

    June 3, 2025
  • Skin Care

    Semaglutide for Weight Loss – Summer Safety and Side Effects Guide

    June 9, 2025

    10 signs it’s time to see an acne expert

    June 8, 2025

    11 Important facts for Botox Botox hood

    June 7, 2025

    Liposcopy: Is it right for you?

    June 7, 2025

    Ideas for father’s day and beyond

    June 4, 2025
  • Sexual Health

    Teenagers and sexual education during the Covid-19 pandemic and beyond

    June 9, 2025

    The odd rise of cases of syphilis to heterosexual men in the UK

    June 8, 2025

    The Role of Certified LGBTQ Certified Sexual Therapist – Sexual Health Alliance

    June 7, 2025

    How Pride paved the way for sexual well -being

    June 5, 2025

    Best male masturbation positions Female

    June 4, 2025
  • Pregnancy

    Love in Melbourne Australia – Tiffany Rose Maternity Blog UK

    June 8, 2025

    How to remain calm with high blood pressure during pregnancy?

    June 7, 2025

    Pink Stork’s flagship product – as shown in “Empowered by Meg Ryan”

    June 7, 2025

    You don’t have to know everything – only that before birth

    June 6, 2025

    Top 100 Names of Girls 2024

    June 5, 2025
  • Nutrition

    The busy mom’s driver for intestinal-brain connection

    June 7, 2025

    Healthy Banana Bread (Child Approved) Sarah Remat

    June 6, 2025

    The secret to the loss of persistent belly fat by registered dieticians

    June 5, 2025

    Why are you always tired and what to do

    June 5, 2025

    20 herbal and wonderful recipes with appetizers

    June 4, 2025
  • Fitness

    Creamy all the toast Avocado bagel (easy, salty breakfast!)

    June 8, 2025

    Men’s Health Month: Dealing longevity vacuum

    June 7, 2025

    Best 12 biceps exercises ranked: build larger and stronger weapons

    June 6, 2025

    Próximamente el 10 de junio: 25 minutes of train de Joel Freeman

    June 5, 2025

    The best weight counter to add to your home gym in your 2025

    June 5, 2025
Healthtost
Home»News»New study reveals molecular mechanism in Alzheimer’s disease
News

New study reveals molecular mechanism in Alzheimer’s disease

healthtostBy healthtostOctober 20, 2024No Comments4 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
New Study Reveals Molecular Mechanism In Alzheimer's Disease
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

A research team at the University of Barcelona Neuroscience Institute (UBneuro) has led a study that describes a new molecular mechanism that affects RNA processing and alters the process of protein synthesis in the brains of Alzheimer’s patients. The study, which has been conducted in post-mortem patient samples and in animal models of the disease, will help design future treatments to treat this dementia and other neurological disorders.

Cristina Malagelada, who led the study, and Genís Campoy-Campos, its first author, published the paper in Nucleic Acid Research. Malagelada is a professor at the UB School of Medicine and Health Sciences and at UBneuro and, along with Campoy-Campos, are members of the Center for Biomedical Research Network on Neurodegenerative Diseases (CIBERNED).

A new function for the RTP801 protein

Alzheimer’s disease is the most common type of dementia and causes a gradual decline in cognition, memory and language skills, as well as emotional and psychiatric disturbances. It is characterized by the accumulation of β-amyloid plaques outside neurons and hyperphosphorylated tau protein inside neurons, which alter brain function and cause cell death.

Now, this study reveals a previously unknown role for the protein RTP801, a stress response factor that is abundant in patients with neurodegenerative diseases such as Alzheimer’s disease. According to the findings, this protein can alter the molecular mechanisms that support neuronal survival by affecting the translation of RNA into proteins.

Malagelada says that “until now we knew that the protein RTP801, which is found in hippocampal neurons, is involved in Alzheimer’s pathology, as we published in a previous article (Cell death and disease2021). Then, we discovered that levels of this protein were significantly elevated in both mouse models of Alzheimer’s and in postmortem samples from patients, and these values ​​correlated with disease progression.”

“At a mechanistic level, we observed that reducing the expression of RTP801 prevented cognitive deficits and inflammation, specifically by attenuating the activation of the hippocampal inflammasome, that is, the machinery that processes cytokines in inflammatory responses and drives gliosis (reactivation and proliferation of glial cells”, continues the expert.

Why is this mechanism vital to neuronal health?

The study describes how the RTP801 factor negatively regulates the activity of the tRNA ligase complex (tRNA-LC), which is critical for processing RNA molecules. In the context of Alzheimer’s disease, higher levels of RTP801 can inhibit this complex and cause problems in RNA splicing and the subsequent production of related proteins, such as brain-derived neurotrophic factor (BDNF), exacerbating cognitive problems in a model Alzheimer’s disease mouse.

Campoy-Campos notes that “in this study, we found that high levels of RTP801 interfere with the tRNA ligase complex, which is responsible for RNA processing, specifically in the process of ligation of its exons after introns are spliced. The process takes place in both the messenger RNA – which contains the information to make the protein – and the transfer RNAs, which carry the amino acids to translate it.” The researcher emphasizes that “this process is crucial for the correct synthesis of proteins in the ribosome, the cellular organelles where the translation of RNA into proteins takes place.”

Interestingly, this interaction between RTP801 and the tRNA ligase complex also affects the RNA binding of a transcription factor called XBP1s. This factor helps cells cope with stress in the endoplasmic reticulum – an organ formed by a series of reservoirs and membrane-bound cavities in the cell’s cytoplasm – and promotes the expression of BDNF, a neurotrophin vital for synaptic transmission, memory and the survival of neurons.

Genís Campoy-Campos, first author

Altered RNA processing – a consequence of high levels of RTP801 – is extremely damaging to neurons, disrupting their ability to synthesize proteins and respond to stress. As Malagelada points out, this altered RNA processing adds a new toxic component to the hitherto known progression of Alzheimer’s disease. “We now bring to the table the toxicity of unbound RNA and its implications as a novel neurodegenerative mechanism in Alzheimer’s disease,” he says.

Enhancing future therapies for the treatment of neurodegenerative diseases

The discovery of new functions of the RTP801 protein could open up future therapeutic options to address the treatment of neurodegenerative pathologies and the maintenance of brain function and neuronal health. In this sense, Malagelada points out that “if we can design inhibitors of the RTP801 protein — which we are currently working on — or preserve the activity of the tRNA ligase complex, we could specifically block the most toxic functions of this agent and to preserve basic neuronal processes’.

The researchers conclude that “this offers a new set of innovative therapeutic options in the context of these neurological disorders.”

Source:

Journal Reference:

Campoy-Campos, et al. (2024). RTP801 interacts with the tRNA ligase complex and deregulates RNA ligase activity in Alzheimer’s disease. Nucleic acid research. doi.org/10.1093/nar/gkae776.

Alzheimers disease mechanism Molecular reveals study
bhanuprakash.cg
healthtost
  • Website

Related Posts

AI converts sights for visual impairments

June 9, 2025

AI model detects brain tumors with high precision using epigenetic fingerprints

June 8, 2025

The new study warns long -term risks from germ transplants

June 8, 2025

Leave A Reply Cancel Reply

Don't Miss
News

AI converts sights for visual impairments

By healthtostJune 9, 20250

Breakthrough AI transforms the way people with visual damage experience the world, giving them tools…

30 minutes Kettlebell Core Workouts to strengthen your abdomen

June 9, 2025

Semaglutide for Weight Loss – Summer Safety and Side Effects Guide

June 9, 2025

Teenagers and sexual education during the Covid-19 pandemic and beyond

June 9, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment Understanding ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

AI converts sights for visual impairments

June 9, 2025

30 minutes Kettlebell Core Workouts to strengthen your abdomen

June 9, 2025

Semaglutide for Weight Loss – Summer Safety and Side Effects Guide

June 9, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.