As obesity in America continues to grow with alarming rates, researchers find that diet and exercise are not the only driving factors. A new scientific review by UCLA Health explains how stress, difficulties and other social challenges can reshape a person’s intestinal bacteria and brain performance in ways that find it difficult to maintain weight.
Published in the magazine Clinical gastroenterology and hepatologyThe document describes how social decisive health factors, such as income, education, access to health care, disadvantages of the neighborhood, discrimination experiences, negative events of children’s life, and isolation and loneliness are key guides in the emergence and priests.
About 40% of US adults have obesity, which contributes to about $ 173 billion to annual healthcare costs. A recent study found that deaths from obesity -related cancer tripled in the US between 1999 and 2020.
Led by the church of Dr. ARPANA, scientific review reveals how the brain microbicide acts as a bridge between a person’s environmental influences and the risk of obesity through the production of various signaling molecules, including hormones stimulation of appetite, inflammatory and inflammatory stimulants. These chemical changes, in turn, influence what a person decides to eat, how often they eat, the amount of food they eat, what kind of food they want, metabolic functions and exercise habits.
“Our findings reveal that dealing with obesity requires more than focusing on individual choices-it is a result of recognizing the powerful role played by social and environmental forces in shaping health, behavior and long-term health results,” UCLA Health. “Reversing the escalation of the obesity epidemic in America requires a dual approach – personalized, fair care for individuals and bold, systematic policy reforms facing the main causes.
“Research shows that social decisive health factors – such as access to nutritional foods, safe spaces for physical activity, access to resources such as hydraulic facilities, grocery stores and quality health care – are powerful risk drivers, obesity drivers, obesity.
The lower socio -economic situation often restricts health education and dependence on cheap, energy -efficiently processed foods. In many disadvantages and communities, limited access to healthy choices – combined with chronic exposure to stress, violence and structural racism, creates the perfect storm for obesity. By adding to this, social isolation disrupts brain networks that regulate appetite and decision -making, increasing the risk of unhealthy nutrition and weight gain.
These social and dietary factors not only affect behavior, but also lead to real, physical changes in the brain’s microbiome system. Chronic exposure to unhealthy foods alter the structure of the brain, affecting the networks that regulate motivation, reward processing and emotional regulation as well as reducing gray matter volume. At the same time, poor diets disturb the makeup of bowel bacteria, fueling inflammation that further undermines self-control and motivation-thus reinforcing an emotional nutrition and desire and dependence on highly processed foods.
Chronic stress, including anxiety and social isolation associated with racism, also alter the brain pathways and guts of the intestinal, promoting inflammation and impairment of self -control, which further leads the risk of obesity, the Church said. “The disadvantage of the neighborhood is also linked to the reduced diversity of the microbial intestine and the highest presence of harmful bacteria – factors that further reduce metabolism and increase the risk of obesity and related diseases.”
In addition, these changes can start prenatal in early childhood. Environmental stressors and social adversity affect the synthesis of the germ and brain communication, defining the stage for lifelong sensitivity to obesity.
The Church said that while constant change requires a strong policy action to tackle the main causes of obesity, individuals can still take preventive measures on a personal level to browse these challenges and support their health in the meantime.
For example, in view of difficult conditions, individuals can support their health, prioritizing nutritional foods within their budget, building social connections and participating in stress reduction activities such as magazine, connection to nature and physical exercise that also prioritize themselves.
At the same time, healthcare providers have a vital role to play not only by controlling today’s social decisive health factors, but also by recognizing the way in which these factors accumulate and evolve over time, which is rarely calculated.
Dr. Arpana Church, co-director, Goodman-Luskin Microbiome Center in Ucla Health
“By understanding these influences and adapting therapeutic plans to tackle biological and psychosocial challenges, providers can offer more personalized designs that improve the results, enables individuals to take control of their health and at the same time support the long -term good.”
Source:
Magazine report:
Sood, R., et al. (2025) Bio-psychosocial and environmental factors that influence brain-gut-microbiome interactions in obesity. Clinical gastroenterology and hepatology. doi.org/10.1016/J.cgh.2025.07.045