Skin microbicide plays an active role in protecting the sun and in immune balance

The skin microbiocide plays an important role in health and diseases. Researchers have now documented that some skin bacteria can protect us from sunlight (UV) especially with metabolism cis-for auanic acid using an enzyme called urocanase. This allows the ability of the skin to refine how it responds to UV radiation the findings of the study in Journal of Research Dermatologypublished by Elsevier, provides an impressive case study that demonstrates the ability of the skin germ to remodel the host’s immune functions.

The skin hosts a huge ecosystem consisting of millions of microorganisms, including bacteria, fungi and viruses. The composition of the skin germ is extremely unique, complex and varies to a large extent depending on the anatomical position. The usual germs, also known as normal microbial or indigenous microbiotics that live in a beneficial or neutral relationship without causing harm, adjusting their metabolism to the pores available in their microenval, to supply our nutrients and our nutrients.

Chief Researcher Vijaykumar Patra, PhD, Center International De Recherche en Infectiologie; Lyon, France and the research unit for photodermatology, Graz Medical University in Austria, explains, “To date, many internal and external factors have been identified that influence the synthesis of microbial skin. These include various individual parameters such as race, gender, age, hormone levels, nutrition and hygiene, but its environmental factors, Skin also plays a role in regulating these answers.

Researchers used a combination of microbial, immunological tests, in vitro Gnotobiotic mice crops and models, which determine all microorganisms, to study how the skin bacteria respond to UVB radiation, the type of ultraviolet radiation radiation that usually causes sunburn. Discovered that some skin bacteria are metabolized specifically cis-For a photopopopodistus of an important chromophore that absorbs the UV radiation of the cornea, postracycinic acid, using an enzyme called Urosanase. Compared to Trans-Eurocanic Acid, cis-For forgiving acid is endowed with strong immunomodulatory properties. This microbial metabolism then restricts the ability of cis-For inacinic acid to inhibit immunoocials, which means that skin bacteria refine our skin response to ultraviolet radiation radiation.

Researchers point out the interesting interaction between sunscreen, cis-For the microbicide between them, competing in and on the corneal layer, as the most superficial layer of the skin.

Co-Investigator Marc Vocanson, PhD, Center International De Recherche en Infectiologie, Lyon, France, Notes, “This is the first time we have shown an immediate metabolic relationship between the radiation of ultraviolet radiation, a molecule derived from the host and bacterial behavior that affects immune function.

Co-Investigator Peter Wolf, MD, Photoderology Research Unit, Graz Medical University, Austria, concludes, concludes, concludes, concludes, concludes “These findings open the door to protection from the sun -based sun, where we not only protect the skin from ultraviolet radiation, but also consider how microbial microbial microbials can alter the immune landscape after the event.

Commenting on the findings, marked expert Anna Di Nardo, MD, PhD, University of California San Diego and San Gallicano Dermatological Institute IRCCS, Rome, he says, he says, “This central study shows that microbial communities are not passive victims cis-forgiven acid. This recently immobilized role of microbial metabolism in shaping ultraviolet tolerance remodeles our understanding of skin barrier – not only as a structural shield but as a metabolically active, microbial regulated interface. With increasing concerns about exposure to ultraviolet radiation, aging skin and cancer, a deeper understanding of this axis offers promising paths of treatment and prevention. “