When it comes to anti-aging skin care, there are some tried and true injectables. Hyaluronic acid fillers and botox are the two most common. However, a new popular treatment for skin rejuvenation emerges. Injections of polynucleotides are becoming increasingly popular for moisturizing, anti-aging and skin repair. Injections of polynucleotides begin to be discussed alternatively with hyaluronic acid fillers, but work in very different ways. So how do you choose the right one for your skin? Let’s break it.
What are hyaluronic acid fillers and polynucleotide injections?
What is hyaluronic acid treatment?
Hyaluronic acid is a natural sugar found on the skin. It helps maintain moisture and gives skin cells a place to grow. Hyaluronic acid fillers are also known as skin fillers. Skin fillers work by adding volume, plastic wrinkles and deeply moisturizing the skin. They are more permanent, but they give an instant phenomenon. On the contrary, the injections of polynucleotides, which focus on cell regeneration.
What is the treatment of polynucleotide?
Polynucleotides are DNA fragments. Specifically in the skin care, they come from fish, usually salmon. That is why polynucleotide injections are sometimes called salmon sperm. They are used to help stimulate skin repair, collagen production and hydration. When injected into the skin, they enhance cell renewal, improve elasticity and reduce redness and inflammation. Polynucleotides are known for their biocompatible results. This means that they encourage the skin to heal and be repaired over time.
Basic differences between polynucleotide and hyaluronic acid
The best choice depends on the needs of your skin. Let’s take a closer look at which treatment works best for different concerns.
| Feature | Polynucleotides Injectison (PN) | Hyaluronic acid (HA) |
|---|---|---|
| Main operation | Skin Repair & Collagen Stimulation | Hydration and reinforcement of tumor |
| How it works | Stimulates the regeneration of cells & healing | Fills and moisturizes the skin directly |
| Best for | Fine lines, skin texture, elasticity, redness | Deep wrinkles, loss of volume, intense hydration |
| Time schedule | Gradual (visible after a few weeks) | Phenomenon |
| Longevity | 6+ months with maintenance | 6-12 months, depending on the type of filling |
| Treatment areas | Face, neck, hands, scalp, stretch marks | Lips, cheeks, under the eyes, jaw, deep wrinkles |
| Side effects | Mild swelling, redness, bruises | Swelling, bruises, risk of parties or migration |
| Best candidates | Those seeking skin regeneration and anti -inflammatory benefits | Those who wish for immediate hydration or tumor restoration |
Can polynucleotides and hyaluronic acid be combined?
Yes! Hyaluronic acid fillers and polynucleotide injections can be used together. In fact, a study given to more than 200 dermatologists using injections of polynucleotides in their practice have shown that they were used with other treatments such as hyaluronic acidic fillers. Some studies show that the use of polynucleotides before fillers can improve and extend the results.
Side effects and safety: injections of polynucleotide against hyaluronic acid Supplements
Both treatments are safe and generally well tolerated. However, they have different side effects. Both can cause swelling and bruising. If you are allergic to fish, polynucleotide injections can cause an allergic reaction. Hyaluronic acid fillers can cause immigration, uneven blood vessels if not properly injected. Regardless of the risk, both treatments should always be performed by an authorized professional.
How much do polynucleotide injections and hyaluronic acid pay?
The cost depends on where you live and who does the treatment. It also depends on how much product is used. Injections of polynucleotides usually cost $ 300- $ 800 per session (3-4 sessions). Hyaluronic acid fillers cost $ 500- $ 1,500 per syringe (1-2 syringes per region). Injections of polynucleotide may appear cheaper per session. But you need more sessions. Hyaluronic fillers cost more per syringe. But they give you quick results with fewer sessions. Regardless of your treatment, you do not want to look for the cheapest provider. You should only get treatments performed by a reliable and licensed skin care professional.
Final verdict: Which one should you choose?
| If you want… | Choose |
|---|---|
| Direct hydration and bitterness | Hyaluronic acid |
| Long-term repair and anti-aging skin | Polynucleotides |
| Reduction of fine and wrinkles | Both (pn for texture, ha for deep wrinkles) |
| Improved Push of Elasticity and Collagen | Polynucleotides |
| Tumor recovery (cheeks, lips, under eyes) | Hyaluronic acid |
| Redness and sensitive skin relief | Polynucleotides |
| A combination approach for best results | Both! (Pn first, then ha) |
For quick results, hyaluronic acid fillers are better. If you are looking for long -term skin improvement, polynucleotide injections can help. For the best results, use both. Talk to a skin professional. They can tell you what’s best for your skin!
References
Arakos AAraco F, Raichi M. Clinical Effectiveness and Safety of Polynucleotides (PN-HPT®) and Cross Hyaluronic Acid for moderate to severe ritholate folds: a perspective, randomized exploratory study. J Cosmet Dermatol. 2023 Jan 22 (1): 146-155. DOI: 10.1111/JOCD.15064. EPUB 2022 May 26. PMID: 35531796; PMCID: PMC10084116.
Cavallini m, Bartoletti E, Maioli L, Massirone A, Pia Palmieri I, Papagni M, Priori M, Trocchi G, as members of Polynucleotides Hpt ™ Priming Board, Collegio Italiano Delle Società Scientifiche di Medicina Estetica of aesthetic medical scientific companies) – SIME, Agorà, sies. Consensus report on the use of PN-HPT ™ (Polynucleotides of High Cleanled Technology) in aesthetic medicine. J Cosmet Dermatol. March 2021 20 (3): 922-928. DOI: 10.1111/JOCD.13679. EPUB 2020 Sep 21. PMID: 32799391; PMCID: PMC7984045.
Lampridou sBassett S, Cavallini M, Christopoulos G. The effectiveness of polynucleotides in aesthetic medicine: a systematic review. J Cosmet Dermatol. 2024 Dec. 8: E16721. DOI: 10.1111/JOCD.16721. Epub in front of printing. PMID: 39645667.
Lee dChoi H, Yoo K, Park Yj, Park HJ, Oh SM, Ji GH, Rah Gc, Shin Dw. Evaluation of current practices and the perceived efficiency of injectable polynucleotide for expanded facial resources between cosmetic doctors: Research -based evaluation. SKIN RES TECHNOL. 2024 SEP, 30 (9): E13738. DOI: 10.1111/srt.13738. PMID: 39233467; PMCID: PMC11375025.
Lee dkOh m, kim mj, oh sm. Clinical effects of polynucleotide with intradermal injections of hyaluronic acid on facial erythosis: Effective redness using polynucleotides. SKIN RES TECHNOL. 2024 Sep 30 (9): E70034. DOI: 10.1111/srt.70034. PMID: 39258788; PMCID: PMC11388635.
Lee D, Kim Mj, Park HJ, Rah Gc, Choi H, Anh St, Ji Gh, Kim Ms, Kim G, Shin Dw, Oh Sm. Current practices and the perceived efficacy of polynucleotides to treat cosmetic doctors. SKIN RES TECHNOL. 2023 SEP, 29 (9): E13466. DOI: 10.1111/srt.13466. PMID: 37753681; PMCID: PMC10485387.
Lee kwaChan Kwl, Lee A, Lee Ch, Wan J, Wong S, Yi Kh. Polynucleotides in Aesthetic Medicine: A review of today’s practices and perceptual efficiency. Int j mol sci. 2024 July 27, 25 (15): 8224. DOI: 10.3390/IJMS25158224. PMID: 39125793; PMCID: PMC11311621.
PortfullyLIEW S, TEE XJ, CHONG I, LO FJ, HO MJ, ONG K, CAVALLINI M. Polynucleotides HPT for Asian skin regeneration and rejuvenation. Clin Cosmet Investig Dermatol. 2024 Feb 13; 17: 417-431. DOI: 10.2147/CCID.S437942. PMID: 38371328; PMCID: PMC10874187.
Park kySeok J, Rho NK, Kim Bj, Kim Long chain polynucleotide information for skin rejuvenation: efficacy and complications in five patients. Dermatol Ther. 2016 Jan-Feb, 29 (1): 37-40. DOI: 10.1111/dth.12299. EPUB 2015 November 2. PMID: 26814448.
Rho nkHan Kh, Cho M, Kim Hs. A study on the cosmetic use of injectable polynucleotide: the model of practice between Korean dermatologists. J Cosmet Dermatol. 2024 Apr 23 (4): 1243-1252. DOI: 10.1111/JOCD.16125. EPUB 2023 Dec 13. PMID: 38093498.
