PMS AND PMDD
STERILITY AND MENTAL HEALTH
PSYCHIATRIC ILLNESS DURING PREGNANCY
Abel KM, Freeman MP. J Clin Psychiatry. 2023 Sep 18;84(5):vtsmdd2136ahc.
Bränn E, Vaina A, DanÃelsdóttir HB, Thordardottir EB, Yang Q, Jakobsdóttir J, Aspelund T, Hauksdóttir A, Valdimarsdóttir UA, Lu D. Arch Womens Ment Health. September 20, 2023.
The total number of ACEs was positively associated with PPD (PR 1.11 per ACE, 95% CI: 1.10-1.11), also among women without psychiatric comorbidities (PR 1.13, 95% CI: 1.11 -1.14). PRs increased in a dose-response manner with the number of ACEs. women who endorsed 5 or more ACEs were twice as likely to experience PPD (PR 2.24, 95% CI: 2.09-2.41). All types of ACE were associated with PND, with the strongest association for emotional neglect by a caregiver (PR 1.53, 95% CI: 1.47–1.59).
The EPDS and EPDS-3A can be used alone or in combination to initially screen for pregnancy anxiety. Under some circumstances, they can even be used to replace the GAD-7 for anxiety screening to reduce the negative impact of over-screening in pregnant women and improve the quality of research data and the efficiency of clinical services.
DRUGS AND PREGNANCY
EPILOGICAL PSYCHIATRIC DISEASE
Dlamini LP, Amelia VL, Shongwe MC, Chang PC, Chung MH. Gen Hosp Psychiatry. 2023 Sep 17 85:35-42.
Eighty-eight (88) cohort studies with a combined sample size of 1,042,448 perinatal women contributed to the meta-analysis. About 37% of pregnant women who had antenatal depression (AD) later had PPD. AD subjects were four times more likely to develop PPD (OR: 4.58; 95% CI = 3.52-5.96). The odds of PPD were higher when AD was observed in the first or third trimester compared to the second trimester. About 12.8% of PPD cases were attributable to AD.
Jester JM, Riggs JL, Menke RA, Alfafara E, Issa M, Muzik M, Rosenblum KL. Front Psychiatry. 2023 Sep 5;14:1048511.
At 3 months post-treatment, the 31 women assigned to Mom Power were half as likely to meet criteria for possible depression (26%) as the 22 women in the control group (55%), with treatment predicting lower incidence of possible depression (OR = 0.13, Pi = 0.015).
Sheng Z, Liu Q, Lin R, Zhao Y, Liu W, Xu Z, Liu Z. J Affect Disord. 2023 Dec 1;342:177-181.
In CSF samples collected at delivery, CSF levels of capric acid, dodecanoic acid, arachidic acid, and behenic acid were negatively associated with PPD symptoms, whereas L-tryptophan was positively associated. Moreover, these five biomarkers can be used as effective prognostic biomarkers for PPD.
Hall SV, Zivin K, Piatt GA, Weaver A, Tilea A, Zhang X, Moyer CA. Psychiatrist September 27, 2023:
The rate of receiving a PMAD diagnosis varied by race and was low overall. Black respondents were less likely than white respondents to receive a diagnosis. Patient characteristics influencing diagnosis also differed by race, indicating that strategies to improve detection of these disorders require a tailored approach.
Wainwright S, Caskey R, Rodriguez A, Holicky A, Wagner-Schuman M, Glassgow AE. BMC pregnancy delivery. 2023 Sep 19 23(1):675.
Participation was high in a pilot PPD screening for fathers in a primary care setting.
Babiy Z, Merza D, Layton H, Bieling PJ, Van Lieshout RJ. Am J Psychother. 23 Aug 2023:appipsychotherapy20220060.
Trained peers may be able to reliably assess the fidelity of a PAI for postpartum depression. This preliminary study represents the first step toward peer-guided feedback as an alternative to expert supervision of peer-administered group CBT for postpartum depression.
Liu QR, Zong QK, Ding LL, Dai HY, Sun Y, Dong YY, Ren ZY, Hashimoto K, Yang JJ. J Affect Disord. 2023 Oct 15; 339:815-822.
Perioperative administration of esketamine did not reduce the incidence of PPD risk in women after elective caesarean section. However, esketamine reduced the use of opioids for pain relief.
Chang CY, Liu SR, Glynn LM. Arch Womens Ment Health. September 22, 2023.
Larger leaves were associated with increased depressive symptoms for women who lost their previous work activities. In addition, women who lost their jobs and were off for 16 weeks or more had higher depressive symptoms at six and 12 months. Finally, the results also showed that women who returned to work only for monetary reasons experienced more depressive symptoms at six months postpartum than those who returned to work for other reasons.
MEDICATIONS AND BREASTFEEDING
PERIRENTAL SUBSTANCE USE
MATERNAL MENTAL HEALTH AND CHILD OUTCOMES
Lugo-Candelas C, Chang L, Dworkin JD, Aw N, Fields A, Reed H, Spann M, Gilchrist MA, Hinds W, Marsh R, Fifer WP, Weissman M, Foerster BU, Manin MG, Silva I, Peterson B, Coelho Milani AC, Gingrich J, Monk C, Duarte CS, Jackowski A, Posner J. J Dev Orig Health Dis. 2023 Sep 21:1-11.
In male children, a history of maternal maltreatment could have transgenerational associations with offspring brain development imaged by MRI that may ultimately lead to changes in behavior and later vulnerability to psychiatric illness.
Yates R, Treyvaud K, Lee KJ, Doyle LW, Cheong JLY, Pace CC, Spittle AJ, Spencer-Smith M, Anderson PJ. J Dev Behav Pediatr. 2023 Sep 1;44(7):e455-e462.
Children born at <30 weeks' gestation showed more mental health symptoms than their peers born at 5 years of age. Maternal postnatal distress was associated with poorer child mental health in both groups, reinforcing the need for early recognition and support of mental health distress in the postpartum period to improve long-term child well-being.
Seebeck J, Sznajder KK, Kjerulff KH. Soc Psychiatry Psychiatr Epidemiol. August 9, 2023.
These findings suggest that maternal experience of adverse psychosocial factors during pregnancy may be an important in utero exposure associated with the pathogenesis of ASD.
Li Q, Sun H, Guo J, Zhao X, Bai R, Zhang M, Liu M. J Affect Disord. 2023 Oct 15; 339:531-537.
Animal study examines gut microbiome as a moderator of prenatal maternal distress on offspring behavior.
