Ozempic and others in a new category of weight loss drugs have been named “The medical sense of the decade. “Are they worth all the advertising campaign?
For a deep dive, please see my primer on this subject. Ozempic: Risks, Benefits and Natural Alternatives for GLP-1 Weight Loss is Available as eBook, Audiobook and Paperback. You can also see my video series free on the Ozempic Topic page or in our YouTube channel. Here are some of the basic takeaways.
What is GLP-1?
A natural hormone in our body, the peptide-1 (GLP-1) that looks like glucagon plays a role in regulating blood sugar, appetite and digestion. Our gastrointestinal tract releases more than 20 different peptide hormones, including GLP-1. Primary stimuli for the secretion of GLP-1 are the meals rich in fats and carbohydratesand the main action of GLP-1 is IMPORTANT IN THE INSTALLATION. The It also slows down our digestion. Delaying the rhythm at which food leaves our stomach not only to help us feel more fully for a longer period of time but also helps with us blood sugar control. When the GLP-1 or a fighter (imitates) drips into the veins of people, the appetite decreases, leading to significant reduced food consumption– Reduce calorie intake 25 to 50 percent.
For GLP-1 medicines
The GLP-1 hormone acts as a repressive appetite by targeting parts of the brain that are responsible for hunger and cravings. GLP-1 secretions do not only align our intestines. Are also in our minds. These new anti -obesity drugs are GLP-1 fightersimitating the action of the hormone by commitment to GLP-1 receptors.
Our body collapses GLP-1 so fast that it doesn’t even make it once around us circulatory systemSo we can’t just take the hormone immediately. Discovered a compound – in the poisonous saliva of a lizard called Monster gila-This mimics GLP-1 but is resistant to distribution. Using this compound as a model, the first GLP-1 fighter was created and approved for the treatment of diabetes about 20 years ago. Instead of clearing the body within two and a half minutes, such as the natural GLP-1, much of the drug remains in the body for two and a half hours. This still means injections twice a day, but then came Linouglutidis, who lasts all day.
What is ozempic?
Finally, semaglutide was developed and characterized as ozempic, which could be injected Just one week. Ozempic was approved in 2017 to treatment of diabetes. Within a few years, a daily oral edition was developed, again for diabetes, but the researchers who conduct these clinical trials have noticed an amazing side effect: People’s appetites declined.
How does ozempic work?
In a way, GLP-1 fighter medicines act as birth control pills. The pill imitates placenta hormonesAs a result, we deceive our body believing that we are pregnant all the time. OZEMPIC-type medicines mimic GLP-1, thus eliminating our body to think about eating all the time. This is the way it calls our hunger driving.
Ozempic for weight loss
To more test until todayMore than 17,000 people were randomized in injections of either high dose of hemiglitis or placebo for four years. Overall, those who lost 9 percent more body weight than those of the placebo group, but all the weight was lost in the first 65 weeks. Although they continued to be injected every week for another three years, they did not lose more weight over the next 143 weeks.
Weight loss tends to the plateau, because the same attempt to reduce calories – either through will, drugs or surgery – is found with increasing resistance, as continuing weight loss increasing the feedback circuit, stimulating it, stimulating it. Our appetite. In the case of GLP-1 drugs, the weight loss caused by the initial decline in appetite is degraded by an apparent exponential increase in calorie intake, as our body increases our hunger again. Within 12 months, this resistance, combined with reduced calorie needs than being lighter, fits the persistent attempt to reduce calories and Weight loss plateaus. And, as soon as we stop taking the drugs, our full appetite continues and we begin to regain the weight we first lost.
The cost of ozempic
Wegovy, the high dose ozempic used for weight loss, cost to $ 1,350 per monthwhich, again, may need to be paid timelessness, since any lost weight can accumulate If you stop taking it. So this could cost More than $ 16,000 a year If it is paid out of pocket for those whose insurance does not cover it.
Ozempic side effects
Most Common side effects Include nausea, vomiting, diarrhea and constipation. The issues of the gall bladder are another side effect. Excess cholesterol from adipose cells can be crystallized in our bile such as Rock Candy, forming gallstones.
Rare but Serious side effects They also emerge. Package inserts for both semaglutide and tirzepatide records a row “warnings and precautions“This includes tumors of thyroid, acute inflammation of the pancreas (pancreatitis), acute gall bladder disease, acute kidney damage (which may come from dehydration due to excess vomiting or diarrhea), allergic reactionsAn increased risk of taking blood sugars, while in drugs that reduce blood sugar, deterioration of ocular diseases for those with type 2 diabetes, an increase in heart rate that requires follow -up and follow -up and suicidal thoughts and behaviors.
What is “Ozempic Face”?
“Ozempic Face” is a term used to describe a deformed appearance of the face Between users of the drug. (Similar accounts have been made “Ozempic butt.“) Media reports have linked the drug to aging of the face, but the loose appearance has been simply attributed to accelerated fat loss in the face. While this interpretation seems logical, a review of the phenomenon concluded that “this explanation cannot fully represent the remarkably accelerated aging of the face …”. Other factors suspected as responsible for the appearance of premature aging facial Loss of mass muscleReduced structural integrity of the skin and changes in stem cell function and hormonal secretion.
Is ozempic safe?
In the first quantitative analysis of a benefit-balancing balance, the researchers concluded that those who achieve a loss of 10 % had a greater than 90 % chance that the benefits of taking drugs compensate for lesions, but the opposite was found only for people who are achieved only one 5 % weight loss.
At the moment, we do not know the long -term damage or benefits, because some of these medicines and dosage timetables are so new. To complicate things, the American Academy of Pediatrics suggested that we offer these medicines for adolescents and even tweens as young as the age of 12. These drugs work by acting on the brainSo who knows what they could have in childhood development and beyond if young people end up taking them for the rest of their lives. Although now we have evidence near-The benefit for a few years, we cannot assume long -term security until proven.
Ozempic alternatives
We do not need to take GLP-1 drugs. Not only can swallowing a vegetable meal more than double secretion GLP-1 compared to a meat meal, but vegetable diets can also cause weight loss by enhancing the metabolic rate of rest and incorporating high Fier Foods that rinse calories away. The largest study of people who eat strictly plants have found that it is about 35 pounds lighter on average.
When we eat a donut, fat, sugar and starch are quickly absorbed, high, before reaching the part of our digestive tract where we produce most of the hormone that suppresses our appetite, GLP-1. Since cells producing GLP-1 in response to calorie exposure are concentrated in End of our digestive tractWhile the majority of the calories we consume are absorbed early, most calories never make it far enough. That is why our appetites are not suppressed too much these days. In terms of GLP-1, when we have this donut, it’s like we’ve never ate anything. There is no doubt that we reach number two.
Our prehistoric ancestors are believed to have consumed up to 100 daily fiber, which is more than six times that most of us get these days. We have evolved the consumption of huge quantities whole vegetable foods-The only fiber positions are in abundance. This allowed the natural mechanisms of satiety to keep us from over -consumption. By consuming the way in which nature is intended, we can release GLP-1 the way nature is intended. This helps to explain why in medical literature, compared to any other consumption that did not include a portion control, a whole food, the vegetable diet has been shown to lead to greater average weight loss from any other diet.
For more information on Ozempic and GLP-1, check these resources:
