A new review highlights the central role of LSD1 (Special Lysine 1station 1) in regulating critical cellular processes and its effects on human diseases. This article illuminates how post-translational modifications (PTMS) affect LSD1 activity, affecting its function in gene regulation and disease progression.
LSD1 is a residual tissue that plays an important role in remodeling chromatin and gene expression by modifying H3 Lysine tissue residues. It interacts with various protein complexes, allowing it to serve both as a transcriptional actuator and as a repressor. Complex modifications of LSD1, including phosphorylation, acetlation, uvicinosis, methylation, swumulosis and nitrozylation, dictate enzymatic activity, hypocritical detection and stability. The split of these modifications has been linked to multiple pathological conditions, including cancer, metabolic disorders, neurological diseases, cardiovascular conditions and bone disorders.
Over -expression of LSD1 has been observed in various tumors, where it facilitates the suppression of tumor suppression genes and promotes the proliferation of cancer cells. LSD1’s interaction with oncogenic pathways contributes to oncogenesis and metastasis, making the promising therapeutic target. In metabolic diseases, LSD1 has been involved in the differentiation of adipose tissue and insulin sensitivity, indicating possible strategies for obesity and diabetes management. In addition, LSD1 is vital to the development of neurodeaulation, with dysfunction associated with autism, Alzheimer’s disease and amyotrophic lateral sclerosis.
The growing set of evidence of the role of LSD1 in gene expression and the mechanisms of the disease opens new ways for targeted treatment. LSD1 inhibitors are currently investigated as possible treatments for cancer and neurological disorders, with the aim of restoring normal cellular function by shaping its activity. The findings presented in this review enhance the importance of post-translational modifications as regulatory mechanisms and emphasize the need for further research on medical precision approaches aimed at LSD1.
By expanding the understanding of LSD1 and its modifications, this research provides a foundation for the development of new therapeutic strategies, providing hope for improved treatments in a series of diseases associated with LSD1 dysfunction.
Source:
Magazine report:
Lee, Y., et al. (2024). The multifaceted role of LSD1 post-translational modifications in cellular processes and pathogenesis of the disease. Genes and diseases. doi.org/10.1016/j.gendis.2024.101307.
