Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

45 Vegetable Summer Picnic Recipes

July 23, 2025

Jacksonville Hiking Trails: Fresh Air & Fun for all

July 23, 2025

Forever Chemicals Cross Placenta and breast milk that affect baby immunity

July 23, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    Forever Chemicals Cross Placenta and breast milk that affect baby immunity

    July 23, 2025

    Targeting of tumor cell stem can keep the key to treating colon cancer more effectively

    July 23, 2025

    Aging skin buckles under pressure leading to wrinkles

    July 22, 2025

    Toti-n-seq breakthrough allows the universal and escalating profile of a cell

    July 22, 2025

    Early use of smartphone connected to poorer mental health in young adults

    July 21, 2025
  • Mental Health

    How mothers who support mothers can help cover the lack of healthcare and other barriers to care

    July 22, 2025

    Do you have to trust a AI mental health application? -Poic details, privacy risks and 7 -point security checklist

    July 19, 2025

    3 ways Canadians can take control of their finances in a time of economic uncertainty

    July 18, 2025

    Exercise can significantly benefit the mental health of adolescents – here they say the items

    July 13, 2025

    Awareness Month for Mental Health 2025: Turn awareness into action

    July 9, 2025
  • Men’s Health

    30 minutes of full body workout to burn fat and enhance strength

    July 23, 2025

    Erythritol changes brain function and may increase the risk of stroke

    July 21, 2025

    Cardio vs. Training Power: Which is better for shrinking medium -age fat?

    July 21, 2025

    New peak health technologies for all men over 40

    July 20, 2025

    Because I care about men’s health … and why should you also – talking about men’s health

    July 19, 2025
  • Women’s Health

    Probiotics of Multiple Executives for Bowel, Skin and Energy Support

    July 23, 2025

    Power beyond the game: Vicky Fleetwood

    July 22, 2025

    Can you get magnesium with multivitamins and other vitamins?

    July 21, 2025

    I wasn’t tired. I was in heart failure.

    July 20, 2025

    These lamps cause migraines, anxiety and even cancer. That’s you

    July 19, 2025
  • Skin Care

    The bridal flash guide with Joanna Vargas

    July 22, 2025

    Think that your sunscreen protects you? New study probably says no

    July 21, 2025

    Your Guide to Resources: both large and small

    July 20, 2025

    Chocolate causes acne? | Eminence organic skin care

    July 19, 2025

    Itching, irritated, angry scalp? Try this

    July 14, 2025
  • Sexual Health

    How to try HIV in Australia: Free, Fast and Private

    July 21, 2025

    Do orgasms change over time?

    July 21, 2025

    7 gender myths collapsing by a special fertility for couples

    July 19, 2025

    New Jersey’s ban on book bans

    July 18, 2025

    I’m Trans Teen. The US government is attacking my community.

    July 18, 2025
  • Pregnancy

    Restore your week with these Storms-Rose Stork

    July 22, 2025

    Why French baby names tend to modern mothers

    July 21, 2025

    Last minute baby gifts that still join each mom

    July 17, 2025

    How to avoid activation and manage it?

    July 16, 2025

    Cortisol connection – pink stork

    July 15, 2025
  • Nutrition

    45 Vegetable Summer Picnic Recipes

    July 23, 2025

    Episode 007: The Power of Critical Thinking: Why Success requires Brave Options with Sean Croxton

    July 22, 2025

    Do you need a glucose screen if you don’t have diabetes?

    July 22, 2025

    Do you have a dessert? Here is 5 natural GLP-1 foods for dessert

    July 21, 2025

    Grammie + Pea Camp 2025 • Kath eats

    July 20, 2025
  • Fitness

    Jacksonville Hiking Trails: Fresh Air & Fun for all

    July 23, 2025

    My healthy stack of sleep: what I use for deep, restorative rest

    July 23, 2025

    New Dumbbell training for beginners (plus my favorite exercises 💪)

    July 22, 2025

    10 healthy ways to launch steam

    July 22, 2025

    10 high -protein breakfast ideas for weight loss

    July 21, 2025
Healthtost
Home»News»Coronary atherosclerosis is prevalent even in low-risk adults with normal cholesterol levels
News

Coronary atherosclerosis is prevalent even in low-risk adults with normal cholesterol levels

healthtostBy healthtostAugust 8, 2024No Comments1 Min Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
Coronary Atherosclerosis Is Prevalent Even In Low Risk Adults With Normal
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

In a recent study published in the journal JACC Advances, investigators in the United States examined the presence of coronary atherosclerosis using coronary computed tomography angiography (CCTA) in asymptomatic adults without traditional risk factors based on levels of low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and apolipoprotein B (apoB). They found that coronary atherosclerosis is common and the prevalence increases with increasing levels of atherogenic lipoproteins, even in low-risk adults without traditional risk factors.

Study: Serum lipoproteins are associated with coronary atherosclerosis in asymptomatic US adults without traditional risk factors. Image Credit: ALIOUI MA / Shutterstock

Record

Atherosclerotic cardiovascular disease (ASCVD) is a major cause of mortality worldwide, mainly due to coronary atherosclerosis, which is known to have an early onset and progress over time. Elevated LDL-C is a major cause of ASCVD, and lowering LDL-C is crucial for prevention. Historically, LDL-C ≥160 mg/dL was considered elevated, while <100 mg/dL was considered optimal. However, these levels may still be insufficient to prevent atherosclerosis or ASCVD. In addition, non-HDL-C and apoB are strong predictors of ASCVD but are rarely assessed in asymptomatic populations. There remains a lack of evidence regarding the relationship between these lipoproteins and coronary atherosclerosis in adults without clinical ASCVD or other risk factors. Therefore, the investigators in the present study investigated the association between subclinical coronary atherosclerosis and atherogenic lipoproteins in asymptomatic, middle-aged US adults without traditional ASCVD risk factors. They hypothesized a potentially important association and aimed to enhance primary diagnostic and preventive strategies used against the condition.

About the study

The data in the present study come from the Miami Heart (MiHeart) study. A total of 1,033 participants from the 40-65 age group and without clinically symptomatic CVD or lipid-lowering therapy were included, with a subgroup of 184 participants having optimal risk factors. People with high-risk conditions such as obesity, high creatinine levels, asthma, cancer or pregnancy were also excluded. The median age of participants was 51 years, 42.1% of them were non-Hispanic White, and 55% were female. Data on demographics, clinical history, and CCTA imaging were obtained. Coronary atherosclerosis was diagnosed using the Agatson method and American Heart Association classification. The study examined the potential association of non-HDL-C, LDL-C, and apoB with coronary atherosclerosis, significant stenosis, coronary artery calcification, and high-risk plaque characteristics. Statistical analysis included the use of t-test, chi-square test, Fisher’s exact tests, and logistic regression models with forward stepwise selection.

Results and discussion

The study cohort had median serum LDL-C, non-HDL-C, and apoB levels of 125, 144, and 94 mg/dL, respectively. The majority of participants had a lower predicted 10-year ASCVD risk, with over 86% having a risk of <5%. Men showed higher body mass index, atherogenic lipoprotein levels and risk of ASCVD compared to women. Approximately 35.9% of participants without traditional ASCVD risk factors had coronary plaque, and the prevalence of coronary and calcified plaque was found to increase progressively with non-HDL-C, LDL-C, and apoB levels. Men showed higher plaque rates and more high-risk characteristics than women. In addition, coronary plaque was observed to become more common with advancing age in both men and women. Multivariate analyzes showed that higher atherogenic lipoproteins, age, male sex, and high lipoprotein(a) were significantly associated with coronary plaque.

In the optimal risk factor subgroup, 21.2% had coronary plaque but less often had severe or high-risk plaque features. Increased age and male gender were observed to be the main predictors of coronary atherosclerosis. At the same time, higher levels of non-HDL-C, LDL-C and apoB were found to remain positively associated with coronary plaque. However, these associations were not statistically significant in this smaller group.

The study is strengthened by its large, community-based cohort of asymptomatic adults, its detailed assessment of both non-calcified and calcified coronary plaque using CCTA, and its focus on a wide range of atherogenic lipoproteins and high-risk plaque characteristics. However, the study is limited by single-site data collection, lack of information on diet and activity, a potentially underpowered subgroup of optimal risk factors, the non-representative sample, and the absence of longitudinal clinical outcomes.

conclusion

In conclusion, the study suggests that among asymptomatic, apparently healthy, middle-aged US adults without traditional ASCVD risk factors, coronary atherosclerosis is common even at serum cholesterol levels considered normal. The prevalence of the condition increases with higher LDL-C, non-HDL-C and apoB. Despite the relatively rare high-risk plaque characteristics of this population, healthcare professionals should consider lowering serum atherogenic lipoproteins through diet, lifestyle changes, or medication to potentially prevent or delay coronary atherosclerosis and improve health outcomes their. In the future, studies could focus on the best timing for risk assessment, the role of adjunctive imaging, and the use of lipid-lowering therapy in low-risk adults.

Our new study at @JACCJournals : Are LDL-C/non-HDL-C/apoB associated with coronary atherosclerosis in low-risk, otherwise healthy US adults without HTN, diabetes, or tobacco use?

— Kamil Faridi MD MSc (@kfaridiMD) August 5, 2024

These findings underscore the importance of lipid-lowering strategies to prevent the development and progression of atherosclerosis—regardless of risk factors. LDL-C, non-HDL-C, and apoB matter even for the healthiest adults.

— Kamil Faridi MD MSc (@kfaridiMD) August 5, 2024

adults Atherosclerosis cholesterol coronary levels lowrisk Normal prevalent
bhanuprakash.cg
healthtost
  • Website

Related Posts

Forever Chemicals Cross Placenta and breast milk that affect baby immunity

July 23, 2025

Targeting of tumor cell stem can keep the key to treating colon cancer more effectively

July 23, 2025

Aging skin buckles under pressure leading to wrinkles

July 22, 2025

Leave A Reply Cancel Reply

Don't Miss
Nutrition

45 Vegetable Summer Picnic Recipes

By healthtostJuly 23, 20250

Explore 45 easy and delicious herbal summer picnic recipes, including vegan dishes and vegetarian foods…

Jacksonville Hiking Trails: Fresh Air & Fun for all

July 23, 2025

Forever Chemicals Cross Placenta and breast milk that affect baby immunity

July 23, 2025

Probiotics of Multiple Executives for Bowel, Skin and Energy Support

July 23, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Improve Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

45 Vegetable Summer Picnic Recipes

July 23, 2025

Jacksonville Hiking Trails: Fresh Air & Fun for all

July 23, 2025

Forever Chemicals Cross Placenta and breast milk that affect baby immunity

July 23, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.