Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

15 easy ways to get 20 grams of protein (Personal Trainer Guide)

June 29, 2025

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

How Barefoot Workout can make you stronger, more athletic and stunning in injuries

June 29, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

    June 29, 2025

    Expansion of genetic code to mammalian cells using pseuduridine -modified codons

    June 29, 2025

    Discover a Dimmer Genetic switch that controls fetal growth

    June 28, 2025

    Who Scientific Advisory Group for the origin of new pathogenic reports for Sars-Cov-2 Origins

    June 28, 2025

    Exploring nervous reactions to mental exhaustion in healthy adults

    June 27, 2025
  • Mental Health

    Which one is right for you? – Talkspace

    June 27, 2025

    Do alternative treatments for bipolar disorder work? Guide based on evidence (2025)

    June 26, 2025

    Data reveals both challenges and positive trends

    June 16, 2025

    How to choose the best yoga teacher training in Rishikesh

    June 14, 2025

    Stress is the most common mental health problem – here is how technology could help manage

    June 11, 2025
  • Men’s Health

    How Barefoot Workout can make you stronger, more athletic and stunning in injuries

    June 29, 2025

    How I turned the chatgpt to my personal nutrition coach and you can also

    June 29, 2025

    Total human care is here: Help men look and feel great now and forever

    June 28, 2025

    Why men ignore sleep apnea (and what they really cost them) – talking about men’s health

    June 28, 2025

    Lessons from a survivor for prostate cancer

    June 26, 2025
  • Women’s Health

    Books I have recently read – The Fitnessista

    June 29, 2025

    Does it support your aesthetic travel your body and mind? Guide

    June 28, 2025

    Eating for real immune support this winter

    June 27, 2025

    What does public health really mean

    June 27, 2025

    How long do you have to expand after MTF? A complete driver to expand – Vuvatech

    June 25, 2025
  • Skin Care

    Sunburn First Aid -7 common mistakes you will regret later

    June 29, 2025

    What is happening first? The step by step guide to build a routine of skin care

    June 28, 2025

    DIY Vitamin C Cucumber The Eye Serum

    June 27, 2025

    Tips for Summer skin care for your best skin

    June 26, 2025

    How a crisis of ingredients led to the best physical form of our deodorant stick

    June 24, 2025
  • Sexual Health

    Can Koles really get chlamydia?

    June 28, 2025

    Overward Visitor and Student Health Insurance in Australia for visa holders

    June 27, 2025

    Disassociation of the latest testosterone treatment lines

    June 27, 2025

    We always know that orgasms were good for you. Now there is proof.

    June 26, 2025

    Josh Duhamel gets testosterone replacement treatment at 52

    June 25, 2025
  • Pregnancy

    AI helps the couple capture after 19 years and 15 IVF attempts

    June 29, 2025

    7 signs your gut can be out of balance

    June 29, 2025

    Helping parents prepare for birth with calm and trust

    June 28, 2025

    Better screen limits for kids: Expert driver for parents

    June 28, 2025

    What is prenatal ability?

    June 27, 2025
  • Nutrition

    25 best vegan taco recipes that are healthy, easy and full of flavor

    June 29, 2025

    Episode 004: Trust your truth against all logic with Angela de la Agua

    June 28, 2025

    Benefits for the health of CoQ10 you should be aware

    June 27, 2025

    Creatine Completion in Menopause: What does science say?

    June 27, 2025

    GLP-1 Enhance the Smoothie recipes push for weight loss

    June 26, 2025
  • Fitness

    15 easy ways to get 20 grams of protein (Personal Trainer Guide)

    June 29, 2025

    Review of the Heat Index: an approach based on evidence

    June 28, 2025

    Bodybuilding Legend Charles Glass’ 5 Favorite Movements Hamstring

    June 27, 2025

    7 Best energy gels 2025, per runners and dieticians

    June 26, 2025

    Different types of training and fitness courses

    June 25, 2025
Healthtost
Home»News»The Golgi apparatus plays a key role in enhancing T-cell function against cancer
News

The Golgi apparatus plays a key role in enhancing T-cell function against cancer

healthtostBy healthtostNovember 24, 2024No Comments4 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
The Golgi Apparatus Plays A Key Role In Enhancing T Cell
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

The Golgi apparatus modifies, sorts and packages proteins to be shipped to their final destinations, whether they are inside or outside the cell.

It is a key function, but poorly studied in the context of cancer immunology, especially compared to other organelles such as mitochondria or the endoplasmic reticulum.

“So we were interested in looking a little bit more at the Golgi apparatus. It’s obviously an important organelle. How does it change or what is its role in T cells in terms of fighting cancer?” said Nathaniel Oberholtzer, MD/Ph.D. student who worked in the laboratory of Shikhar Mehrotra, Ph.D., co-head of the Cancer Biology & Immunology Research Program at MUSC Hollings Cancer Center and scientific director of the Center for Cellular Therapy at MUSC College of Medicine.

As it turns out, the healthy functioning of the Golgi apparatus has a lot to do with how well T-cells work at killing cancer cells. Understanding how a signaling pathway alleviates Golgi stress, allowing it to perform properly, points to a potential new therapeutic target for researchers to pursue to boost T-cells. Not only that, but Oberholtzer’s research shows how the Golgi could be used as a biomarker to select the strongest T-cells for immunotherapy.

Oberholtzer, as first author, and Mehrotra, as senior author, along with a team of Hollings scientists published the research this month in Science Advances.

T-cells, part of the immune system, can kill cancer cells. CAR-T cells are T-cells that have been modified in the laboratory to attach to proteins on the surface of a person’s cancer cells. CAR-T cells are custom-made for each patient.

Both T-cells and CAR-T cells can be “exhausted” in the hostile tumor microenvironment. Mehrotra’s lab is looking at ways to boost these cells so they can fight cancer longer.

The whole tumor microenvironment is favorable for the tumor itself, but not for the other cells that try to get in there.”


Shikhar Mehrotra, Ph.D., co-head of the Cancer Biology and Immunology Research Program at MUSC Hollings Cancer Center

Just like humans, cells are constantly under stress – stress from biochemical reactions that have become unbalanced and mechanical stress from movement. Temporary stress can be good. Stressing your muscles through exercise strengthens them, and transient stress on the cells can trigger a response that ultimately strengthens them.

“But if that stress stays there, as it does in the tumor microenvironment, the cells are just under constant stress, and that will lead to a very different phenotype and death,” Mehrotra said.

However, the researchers found that treating the Golgi apparatus with hydrogen sulfide created T-cells that could require more stress.

“Hydrogen sulfide is a gaseous signaling molecule that is present in almost all types of mammalian cells. Typically, it is a byproduct of different cellular processes, but it has actually been shown to have very important signaling roles as well,” Oberholtzer said.

“It can modify proteins through a process called sulfidation, where it modifies cysteine ​​residues and can change their activity.”

In this work, Oberholtzer found that this sulfation process, by modifying a protein called Prdx4 within the Golgi apparatus, provides protection in an oxidative setting.

“When you have the stressors that the tumor microenvironment puts on T-cells, you get a disruption or fragmentation of the Golgi apparatus where it’s basically unable to do its job. Hydrogen sulfide protects against that disruption,” Oberholtzer said. .

Examining this protective effect then led the researchers to take a closer look at the Golgi apparatus itself.

“Essentially, if you just use the Golgi apparatus as a simple indicator, if T cells have a lot of Golgi versus less, the ones with more Golgi are much more potent at killing cancer cells and controlling tumors,” Oberholtzer explained.

Using cell sorting technology at the Flow Cytometry & Cell Sorting Shared Resource at Hollings, the researchers sorted T-cells according to the amount of Golgi they contained. The top 30% was called Golgi-hi and the bottom 30% was called Golgi-lo.

“Essentially, all high-Golgi-expressing cells have a very different phenotype. They are less exhausted and are much more potent at controlling tumors,” Mehrotra said.

This preclinical work suggests that sorting T-cells into Golgi-hi and Golgi-lo and reinfusing only Golgi-hi cells into a patient would create a better chance of tumor control.

“Right now, we’re working to do some validation studies at the Cell Therapy Center so we can potentially start a clinical trial to see if this also has translational potential,” Oberholtzer said.

More work is also needed to understand the role of Golgi stress when all organelles in a cell are under stress due to the tumor microenvironment.

Source:

Medical University of South Carolina

Journal Reference:

Oberholtzer, N., et al. (2024). The H 2 S-Prdx4 axis moderates Golgi stress to enhance the immunotherapeutic response of tumor-reactive T cells. Advances in Science. doi.org/10.1126/sciadv.adp1152.

apparatus cancer Enhancing Function Golgi key plays Role Tcell
bhanuprakash.cg
healthtost
  • Website

Related Posts

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

Expansion of genetic code to mammalian cells using pseuduridine -modified codons

June 29, 2025

Discover a Dimmer Genetic switch that controls fetal growth

June 28, 2025

Leave A Reply Cancel Reply

Don't Miss
Fitness

15 easy ways to get 20 grams of protein (Personal Trainer Guide)

By healthtostJune 29, 20250

The acquisition of several proteins in your diet is vital to muscle repair, satiety and…

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

How Barefoot Workout can make you stronger, more athletic and stunning in injuries

June 29, 2025

Books I have recently read – The Fitnessista

June 29, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment Understanding ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

15 easy ways to get 20 grams of protein (Personal Trainer Guide)

June 29, 2025

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

How Barefoot Workout can make you stronger, more athletic and stunning in injuries

June 29, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.