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Home»News»Vutrisiran shows potential to become the new standard of care for rare heart diseases
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Vutrisiran shows potential to become the new standard of care for rare heart diseases

healthtostBy healthtostAugust 30, 2024No Comments3 Mins Read
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Vutrisiran Shows Potential To Become The New Standard Of Care
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Vutrisiran significantly improved mortality, cardiovascular events and markers of disease progression in patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM), according to the latest research presented in a Hot Line session today at the ESC 2024 Conference.

ATTR is a progressive, fatal disease in which the misfolded transthyretin protein accumulates as amyloid deposits in various parts of the body, often damaging the heart. We investigated whether a novel RNA interference (RNAi) therapeutic drug, vutrisiran, which targets transthyretin production, could improve clinical outcomes in patients with ATTR-CM, and the results were promising.”


Marianna Fontana, Principal Investigator, Professor, from University College London, Royal Free Hospital, London, UK

HELIOS-B was a randomized, double-blind trial in patients with ATTR-CM (hereditary or wild-type) who had evidence of cardiac amyloidosis by echocardiography and confirmed ATTR amyloid deposition. Patients were randomized 1:1 to vutrisiran 25 mg or placebo administered subcutaneously once every 3 months for up to 36 months. If the patient was already receiving treatment with the disease stabilizer tafamidis, it was continued.

The two primary endpoints were a composite of all-cause mortality and recurrent cardiovascular events when the last patient reached month 33, assessed in the overall population and in patients receiving vutrisiran monotherapy (ie, those not receiving tafamidis at baseline). . Secondary endpoints (assessed in the overall population and in those treated with vutrisiran monotherapy) were all-cause mortality up to 42 months, change from baseline to 30 months in functional capacity (6-minute walk test), quality of life (Kansas City Cardiomyopathy Questionnaire General Summary) and the New York Heart Association (NYHA) course.

In total, 655 patients were recruited from 87 centers in 26 countries. The median age was 76.5 years and 92.5% were male. More than three quarters (77.6%) had NYHA class 2 heart failure and 40% were receiving tafamide at baseline.

The trial met its primary endpoints. Vutrisiran significantly reduced the risk of all-cause mortality and recurrent cardiovascular events by 28% in the overall population (hazard ratio [HR] 0.72; 95% confidence interval [CI] 0.56-0.93; p=0.01) and by 33% in the monotherapy population (HR 0.67, 95% CI 0.49-0.93, p=0.016). In a prespecified subgroup analysis, the composite of all-cause mortality and recurrent cardiovascular events was reduced by more than 20% in patients on tafamide background (HR 0.79; 95% CI 0.51–1.21).

Vutrisiran reduced all-cause mortality over 42 months by 36% in the overall population (HR 0.64; 95% CI 0.46-0.90; p=0.01) and by 35% in the monotherapy population (HR 0.65; 95% CI 0.44-0.97; p=0.045) versus placebo. Other secondary endpoints related to functional capacity, health status, and quality of life were significantly improved with vutrisiran versus placebo.

The majority of side effects were mild or moderate with vutrisiran. Adverse events leading to study drug discontinuation were similar in the vutrisiran (3.1%) and placebo (4.0%) groups.

Professor Fontana concluded: “Vutrisiran was highly effective and well tolerated in this modern population representative of patients we see in our clinics, with consistent benefits regardless of tafamide treatment background. Our findings suggest that vutrisiran has the potential to be the new standard of care This trial is also important as it is the first to show the benefit of gene silencers in any type of cardiomyopathy.

Source:

European Society of Cardiology (ESC)

care diseases heart potential Rare shows Standard Vutrisiran
bhanuprakash.cg
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