A new research document was published in Aging (Aging) On February 18, 2025, Volume 17, Issue 2, entitled “Cumulus cell landscape by patients <38 years of age with a history of poor ovarian response (POR) undergoing platelet -rich treatment (PRP).
Researchers from Ivirma New Jersey, the Yale School of Medicine, Yale University and Acibadem Mehmet Ali Aydinlar University studied how a healing rich treatment (PRP) can help women with poor ovarian response. Their results suggest that PRP can enhance ovarian rejuvenation and improve egg quality, possibly increasing pregnancy success rates for women undergoing in vitro Fertilization (IVF).
Reduced ovarian reserve is an important challenge in fertility treatments, affecting many women undergoing IVF. It is associated with fewer eggs that are collected and lower rates of success in pregnancy. Some studies have explored the concentration of PRP-A of growth factors derived from the patient’s blood as a possible treatment for the rejuvenation of ovarian function. However, the biological effects of PRP treatment at the molecular level remain unclear.
In this study, the research team, led by the first writer Leah M. Roberts and the corresponding writer Emre Seli, analyzed Cumulus cells, specialized egg cells using RNA sequence technology. Samples were collected by women aged 18 to 37 years with poor ovarian response, who either received PRP treatment or standardized treatment before IVF.
The results showed significant differences in gene expression between the two groups. Samples undergoing PRP treatment showed increased activity in genes related to metabolism, cell survival and communication between cells, which are critical to egg growth and fertility. A key finding was that PRP influenced carbohydrate metabolism in cumulus cells. This is essential, as Cumulus cells provide energy to the developing egg and previous research has linked metabolic health to fetal quality. The PRP also appeared to regulate the paths associated with cell proliferation and scheduled cell death, suggesting that it can help support egg survival.
“Our findings show that PRP therapy regulates some pathways that could help activate follicles and maturing oocytes.”
Although PRP has been used in medicine to heal wounds and tissue repair, its role in fertility therapy is still under investigation. Some clinical trials have shown improved ovarian reserve indicators after PRP treatment, while others have not found immediate benefit for pregnancy rates. This study sheds light on how PRP affects Cumulus cells, providing valuable knowledge of its potential for improving fertility therapies.
Researchers hope that further studies will help improve PRP treatments, determine the best protocols and determine which patients can benefit more. By understanding the molecular effects of PRP on ovarian cells, scientists can develop targeted fertility therapies to support women who are infertility due to reduced ovarian reserve.
Source:
Magazine report:
Roberts, lm, et al. (2025). The transcriptional landscape of Cumulus cells from patients <38 years of age with a history of poor ovarian response (POR) who have been treated with platelet -rich plasma (PRP). Aging. doi.org/10.18632/aging.206202
