Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

Master the Seated Ab Pike Compression: The ultimate deep core and Flexor Hip exercise for serious lifters

July 25, 2025

Heavy smoking is linked to atrophy in Alzheimer’s brain areas

July 25, 2025

What are we watching: Medicaid matters more than ever

July 25, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    Heavy smoking is linked to atrophy in Alzheimer’s brain areas

    July 25, 2025

    Creatine can enhance neuroprotection through energy routes

    July 25, 2025

    Here’s the ACA Premium hikes

    July 24, 2025

    Coverage exceeds opponents in timely detection of covid mutations

    July 24, 2025

    Forever Chemicals Cross Placenta and breast milk that affect baby immunity

    July 23, 2025
  • Mental Health

    How mothers who support mothers can help cover the lack of healthcare and other barriers to care

    July 22, 2025

    Do you have to trust a AI mental health application? -Poic details, privacy risks and 7 -point security checklist

    July 19, 2025

    3 ways Canadians can take control of their finances in a time of economic uncertainty

    July 18, 2025

    Exercise can significantly benefit the mental health of adolescents – here they say the items

    July 13, 2025

    Awareness Month for Mental Health 2025: Turn awareness into action

    July 9, 2025
  • Men’s Health

    Prostate cancer and erectile dysfunction

    July 24, 2025

    30 minutes of full body workout to burn fat and enhance strength

    July 23, 2025

    Erythritol changes brain function and may increase the risk of stroke

    July 21, 2025

    Cardio vs. Training Power: Which is better for shrinking medium -age fat?

    July 21, 2025

    New peak health technologies for all men over 40

    July 20, 2025
  • Women’s Health

    What are we watching: Medicaid matters more than ever

    July 25, 2025

    How do you treat the vagina? Effective, non-relief-Vuvatech, non-surgical options

    July 24, 2025

    Probiotics of Multiple Executives for Bowel, Skin and Energy Support

    July 23, 2025

    Power beyond the game: Vicky Fleetwood

    July 22, 2025

    Can you get magnesium with multivitamins and other vitamins?

    July 21, 2025
  • Skin Care

    Bicarb, magnesium and search for perfect Pit formula

    July 24, 2025

    All thermal flx | About aesthetics

    July 24, 2025

    The bridal flash guide with Joanna Vargas

    July 22, 2025

    Think that your sunscreen protects you? New study probably says no

    July 21, 2025

    Your Guide to Resources: both large and small

    July 20, 2025
  • Sexual Health

    3 Sti you can catch even if you are using a condom

    July 25, 2025

    How to try HIV in Australia: Free, Fast and Private

    July 21, 2025

    Do orgasms change over time?

    July 21, 2025

    7 gender myths collapsing by a special fertility for couples

    July 19, 2025

    New Jersey’s ban on book bans

    July 18, 2025
  • Pregnancy

    67 Perfect Baby Book Inscriptions

    July 24, 2025

    Restore your week with these Storms-Rose Stork

    July 22, 2025

    Why French baby names tend to modern mothers

    July 21, 2025

    Last minute baby gifts that still join each mom

    July 17, 2025

    How to avoid activation and manage it?

    July 16, 2025
  • Nutrition

    45 Vegetable Summer Picnic Recipes

    July 23, 2025

    Episode 007: The Power of Critical Thinking: Why Success requires Brave Options with Sean Croxton

    July 22, 2025

    Do you need a glucose screen if you don’t have diabetes?

    July 22, 2025

    Do you have a dessert? Here is 5 natural GLP-1 foods for dessert

    July 21, 2025

    Grammie + Pea Camp 2025 • Kath eats

    July 20, 2025
  • Fitness

    Master the Seated Ab Pike Compression: The ultimate deep core and Flexor Hip exercise for serious lifters

    July 25, 2025

    6 Best Hiit Training Shoes of 2025, per trainers

    July 25, 2025

    Jacksonville Hiking Trails: Fresh Air & Fun for all

    July 23, 2025

    My healthy stack of sleep: what I use for deep, restorative rest

    July 23, 2025

    New Dumbbell training for beginners (plus my favorite exercises 💪)

    July 22, 2025
Healthtost
Home»Men's Health»Omega-3 fatty acids show potential in protecting brain health in older adults
Men's Health

Omega-3 fatty acids show potential in protecting brain health in older adults

healthtostBy healthtostAugust 7, 2024No Comments4 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
Omega 3 Fatty Acids Show Potential In Protecting Brain Health In
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

Recent JAMA Network Open The study evaluates the role of omega-3 polyunsaturated fatty acids (PUFAs) in reducing white matter mass (WML) and degeneration of neuronal integrity in older adults.

Study: ω-3 PUFA for secondary prevention of white matter lesions and breakdown of neuronal integrity in older adults: A randomized clinical trial. Image credit: Bk87 / Shutterstock.com

What is WML stacking?

Brain WML accumulation is associated with an increased risk of cognitive decline and Alzheimer’s disease (AD). Pathophysiological mechanisms involved in this association include reduced regenerative capacity of oligodendrocytes, cerebral hypoperfusion, degeneration of the blood-brain barrier, and endothelial cell activation. Although periventricular WMLs may indicate microglial activation, deeper subcortical WMLs may be more indicative of progressive myelin loss, astrogliosis, and axonal degeneration.

Reduced WML burden has been associated with dietary bioactive lipids such as eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and ω-3 PUFAs. ω-3 PUFAs may act as lipophilic substrates for the synthesis of inflammation-resolving metabolites, thereby shifting cell metabolism and signaling toward a reduced inflammatory state. Previous studies have shown the ability of ω-3 PUFAs to reduce endothelial and immune cell surface CD54 protein expression, which may increase blood-brain barrier permeability and microglial cytokine release.

Meta-analyses of clinical trials have shown that plasma ω-3 levels can be directly associated with up to 25% of WML variants. In addition, higher levels of ω-3 PUFAs have been associated with a 40% reduction in the likelihood of WML in older adults. Therefore, it is important to elucidate whether ω-3 therapy offered to individuals with WML accumulation and suboptimal ω-3 status can mitigate the progression of WML and the breakdown of neuronal integrity.

About the study

The current placebo-controlled, quadruple-blind, randomized clinical trial was conducted in Oregon Health & Science University between 2014 and 2019. Treatment stratification was performed using the apolipoprotein E e4 allele (APOE*E4) carrier status and all results were compared to a placebo group.

The primary outcome of the study was the annual progression of WML, measured using magnetic resonance imaging (MRI). Fractional anisotropy diffusion tensor imaging (DTI-FA) was also used to assess the breakdown of neuronal integrity.

The study cohort included people aged 75 years and older without dementia. Study participants also had suboptimal plasma ω-3 PUFA levels of less than 5.5 percent of total body weight, as well as WMLs greater than or equal to 5 cm3.

A three-year treatment with 1.65 g of ω-3 PUFA, consisting of 975 mg of EPA and 650 mg of DHA, was administered along with a soybean oil placebo matched for appearance, taste, and odor.

Study findings

The ω-3 treatment group showed a smaller annual progression of crude WML compared to the placebo group. However, this difference was not statistically significant. These results were similar for disruption of neuronal integrity, in which the ω-3 group showed a smaller, but not statistically significant, drop in DTI-FA. Mean annual change in abdominal volume and change in total brain volume were not different between groups.

The average annual growth of WMLs in APOE*E4 The carriers treated with ω-3 was lower than in the placebo group, but not statistically significant. For APOE*E4 non-carriers, no difference in mean annual increase in WML was observed in the ω-3 and placebo groups.

Among APOE*E4 carriers, h The mean annual DTI-FA decline of the treatment group was significantly lower than that of the placebo group. Similarly, mean annual DTI-FA decline for APOE*E4 non-carriers was not different between the treated and control groups.

Adverse events (AEs) or serious AEs (SAEs) did not differ between groups. Sixteen study participants experienced SAEs in the two study groups and 26 participants were hospitalized, which included 12 and 14 subjects from the treatment and placebo groups, respectively. There were five deaths in the ω-3 group and one in the placebo group.

AEs occurred in 44 and 41 participants in the ω-3 and placebo groups, respectively. AEs included traumatic falls, gastrointestinal disorders, and musculoskeletal and connective tissue disorders.

The mean annual increase in subcortical and periventricular WML was lower in the ω-3 group compared to the control group. This pattern was similar for mean annual DTI radial diffusion and mean DTI diffusion increment. For executive cognitive function z-scores, no differences were observed between the treatment group and the control group.

conclusions

The findings of the study show that an ω-3 treatment was well tolerated and safe but ineffective in achieving a significant reduction in WML progression and breakdown of neuronal integrity in individuals at increased risk of dementia. However, for APOE*E4 carriers, the reduction in the breakdown of neuronal integrity was significant, suggesting the enhanced effects of omega-3 for these individuals.

Journal Reference:

  • Shinto, LH, Murchison, CF, Sillbert, LC, et al. (2024) ω-3 PUFA for secondary prevention of white matter lesions and breakdown of neuronal integrity in older adults: A randomized clinical trial. JAMA Network Open 7(8). doi:10.1001/jamanetworkopen.2024.26872
acids adults brain fatty health older Omega3 potential Protecting show
bhanuprakash.cg
healthtost
  • Website

Related Posts

Heavy smoking is linked to atrophy in Alzheimer’s brain areas

July 25, 2025

Prostate cancer and erectile dysfunction

July 24, 2025

30 minutes of full body workout to burn fat and enhance strength

July 23, 2025

Leave A Reply Cancel Reply

Don't Miss
Fitness

Master the Seated Ab Pike Compression: The ultimate deep core and Flexor Hip exercise for serious lifters

By healthtostJuly 25, 20250

The torn abdomen is one thing and the power of the core is another. Can…

Heavy smoking is linked to atrophy in Alzheimer’s brain areas

July 25, 2025

What are we watching: Medicaid matters more than ever

July 25, 2025

6 Best Hiit Training Shoes of 2025, per trainers

July 25, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Improve Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

Master the Seated Ab Pike Compression: The ultimate deep core and Flexor Hip exercise for serious lifters

July 25, 2025

Heavy smoking is linked to atrophy in Alzheimer’s brain areas

July 25, 2025

What are we watching: Medicaid matters more than ever

July 25, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.