An international study reveals that strengthening green could be a powerful tool that protects the brain from the harmful effects of contaminated air associated with Alzheimer’s and dementia worldwide.
Study: Green modified PM correlation2.5 and ozone with global illness burden on Alzheimer’s disease and other dementia. Credit Picture: AminSen/Shutterstock.com
A recent study at Scientific reports Investigated whether the energetic affects the correlation between particles (PM) with a diameter of less than 2.5 microfore (PM2.5) and ozone, and if this relationship affects the burden of the disease associated with Alzheimer’s disease (AD) and other dementia.
The correlation between dementia and air pollution
Dementia is a collection of symptoms associated with a decrease in cognitive ability, such as memory loss, difficulty with thinking, and reduced problem -solving ability that affect everyday life. AD is a type of dementia, which has been recognized as the seventh main cause of death worldwide. About 55 million people worldwide have been diagnosed with AD and this number has been predicted to increase by up to 79 million by 2030 and 139 million by 2050.
The global cost of health care has increased significantly due to the high prevalence of dementia. Given the increased prevalence, it is vital to identify modified risk factors, in particular for the prevention of ad and other dementia and to reduce the economic weight of the disease. The World Health Organization (WHO) and the Lancet Committee have independently identified air pollution as an emerging AD risk factor.
Atmospheric pollutants cause oxidative stress and brain neuropharmacy, thereby increasing the risk of multiple diseases, including metabolic disorders, cardiovascular conditions and dementia. Previous studies have created a correlation between PM2.5 and advertising. In 2015, about 28% of deaths and 30% of disability adaptation years (DALY) were associated with dementia caused by the PM environment2.5 pollution.
Interestingly, a large -scale US -based study emphasized that the highest green neighborhood reduces the risk of ad and relative dementia. This incident has been attributed to a greener environment, reducing stress by promoting physical activity and relieving the adverse effects of air pollution. Many studies have not explored how much greener environment affects the association between air pollution and the global illness of AD and other dementia.
For the study
The current ecological study was aimed at examining the relationship between atmospheric pollutants and AD cargo worldwide and evaluating the ability to modify this correlation through a more green environment.
All relevant data on the incidence of AD and other dementia, relative deaths and Daly were obtained from the global database of the global database of the global burden on the disease (GBD). The data of the current study came from 162 countries, extending in 2010, 2011, 2014, 2015, 2016 and 2017.
PM2.5 and Ozone, the two most extensively studied atmospheric pollutants in the GBD database, were examined. To evaluate the exposure to green state, this study used enhanced vegetation ratio data (EVI) and in a normalized vegetation index (NDVI) at the country level (NDVI) from the Moderate Moderate (MODIS) display. NDVI and EVI values range from -0.2 to 1.0, where the highest prices approaching 1.0 represent larger green, while any negative values highlight the cloud cover, snow or water bodies.
Study findings
The current study estimates that the global rate of ad and other dementia, mortality and Daly is 55.52, 12.48 and 206.94 per 100,000 population, respectively. The global spatial distribution analysis revealed that the highest dominance of ad, death and Daly due to ad and other dementia appeared in Japan in 2017, followed by Italy. In contrast, Qatar and the United Arab Emirates showed the lowest incidence of these diseases.
During the study periods, NDVI and EVI values were estimated to be 0.56 and 0.33, respectively. In addition, pm2.5 and ozone is estimated to be 23.13 µg/m3 and 39.96 ppb, respectively. Compared to the rest of the world, a higher density density in America and Oceania was observed.
According to the global landscape, the media levels PM2.5 And ozone was higher in Asia and Africa and lower in Europe, Oceania and America. Spearman correlations between atmospheric pollutants and greenery ranged between -0.36 and -0.40, indicating negative and moderate correlations.
Was observed statistically significant correlation between PM2.5 And the ozone and weight of ad disease and other dementia. In a fully customized model, an increase in 10 points in PM2.5 And the ozone was associated with an increase of 2.0% and 1.9% in the rate of AD and other dementia, respectively. The same exposure levels were associated with an increase in mortality by 2.8% and 9.5% and an increase of 2.2% and 6.7% in DALY rate, respectively.
A strong negative correlation was observed between green and dementia, especially on moderate levels of green, with weaker or non -significant compounds at very high green levels, indicating a non -linear relationship. The burden of the disease was significantly higher in countries with low socio -demographic index (SDI) compared to the medium or high SDI categories. Similarly, a higher ad and other rates of dementia was associated with countries with low gross national income (GNI).
The current study showed that both PM2.5 And the ozone was associated with reduced harmful effects on the burden of dementia (and not with the real “protective” effect) in areas with high levels of green and that in some of the highest greenery quarters, pollutant-seeds became insignificant or even insignificant.
Conclusions
The findings here show a positive correlation between the annual gatherings of PM2.5 And the ozone exposure and the impact, the deaths and the DALYS of AD and other dementia. A greener environment could mitigate this correlation, especially at levels of moderate to high density. As a result, increasing green space worldwide will positively affect health, although the protective effects of greenity may not increase linearly at higher levels of vegetation.
Magazine report:
- Peng, W and Liu, T. (2025) Green concern modified PM correlation2.5 And ozone with a global disease burden on Alzheimer’s disease and other dementia. Scientific reports. 15 (1), 1-9. https://doi.org/10.1038/S41598-025-11552-3. https://www.nature.com/articles/S41598-025-11552-3