Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

Who certifies Surinam as free malaria after decades of attempts

June 30, 2025

Does psychiatric drug kill creativity? Rejecting Van Gogh’s myth

June 30, 2025

The Role of Phytandrogens in BPH

June 30, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    Who certifies Surinam as free malaria after decades of attempts

    June 30, 2025

    The new AI tool helps clinical doctors identify standards of brain activity associated with nine types of dementia

    June 30, 2025

    Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

    June 29, 2025

    Expansion of genetic code to mammalian cells using pseuduridine -modified codons

    June 29, 2025

    Discover a Dimmer Genetic switch that controls fetal growth

    June 28, 2025
  • Mental Health

    Does psychiatric drug kill creativity? Rejecting Van Gogh’s myth

    June 30, 2025

    Which one is right for you? – Talkspace

    June 27, 2025

    Do alternative treatments for bipolar disorder work? Guide based on evidence (2025)

    June 26, 2025

    Data reveals both challenges and positive trends

    June 16, 2025

    How to choose the best yoga teacher training in Rishikesh

    June 14, 2025
  • Men’s Health

    The Role of Phytandrogens in BPH

    June 30, 2025

    Just 150 minutes of exercise per week could prediabetes reversed

    June 30, 2025

    How Barefoot Workout can make you stronger, more athletic and stunning in injuries

    June 29, 2025

    How I turned the chatgpt to my personal nutrition coach and you can also

    June 29, 2025

    Total human care is here: Help men look and feel great now and forever

    June 28, 2025
  • Women’s Health

    Top Home workouts for women 10 exercises to lose belly fat quickly

    June 30, 2025

    Books I have recently read – The Fitnessista

    June 29, 2025

    Does it support your aesthetic travel your body and mind? Guide

    June 28, 2025

    Eating for real immune support this winter

    June 27, 2025

    What does public health really mean

    June 27, 2025
  • Skin Care

    Term Science: Why these tiny bottles are loud

    June 30, 2025

    Sunburn First Aid -7 common mistakes you will regret later

    June 29, 2025

    What is happening first? The step by step guide to build a routine of skin care

    June 28, 2025

    DIY Vitamin C Cucumber The Eye Serum

    June 27, 2025

    Tips for Summer skin care for your best skin

    June 26, 2025
  • Sexual Health

    What kind of professional community is most important to you? Exploring the benefits of SHA’s sex network – Alliance of Sexual Health

    June 30, 2025

    Can Koles really get chlamydia?

    June 28, 2025

    Overward Visitor and Student Health Insurance in Australia for visa holders

    June 27, 2025

    Disassociation of the latest testosterone treatment lines

    June 27, 2025

    We always know that orgasms were good for you. Now there is proof.

    June 26, 2025
  • Pregnancy

    AI helps the couple capture after 19 years and 15 IVF attempts

    June 29, 2025

    7 signs your gut can be out of balance

    June 29, 2025

    Helping parents prepare for birth with calm and trust

    June 28, 2025

    Better screen limits for kids: Expert driver for parents

    June 28, 2025

    What is prenatal ability?

    June 27, 2025
  • Nutrition

    25 best vegan taco recipes that are healthy, easy and full of flavor

    June 29, 2025

    Episode 004: Trust your truth against all logic with Angela de la Agua

    June 28, 2025

    Benefits for the health of CoQ10 you should be aware

    June 27, 2025

    Creatine Completion in Menopause: What does science say?

    June 27, 2025

    GLP-1 Enhance the Smoothie recipes push for weight loss

    June 26, 2025
  • Fitness

    The success story of the AFPA Students – Dr. Nikki Letoya White

    June 30, 2025

    15 easy ways to get 20 grams of protein (Personal Trainer Guide)

    June 29, 2025

    Review of the Heat Index: an approach based on evidence

    June 28, 2025

    Bodybuilding Legend Charles Glass’ 5 Favorite Movements Hamstring

    June 27, 2025

    7 Best energy gels 2025, per runners and dieticians

    June 26, 2025
Healthtost
Home»News»Genetic variants associated with Parkinson’s disease more common than estimated
News

Genetic variants associated with Parkinson’s disease more common than estimated

healthtostBy healthtostJuly 30, 2024No Comments4 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
Genetic Variants Associated With Parkinson's Disease More Common Than Estimated
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

New research has discovered that genetic variants associated with Parkinson’s disease (PD) are more common than researchers previously thought. Researchers in the Parkinson Foundation-supported GENEration PD study – which met its goal of 15,000 participants ahead of schedule this spring – found that 13% of participants have a genetic form of PD, which is an important observation in compared with long-term estimates. Results from the first 3.5 years of the study, which looked at a broad North American cohort, were published in the peer-reviewed journal Brain.

PD GENEration, which screens for clinically relevant genes associated with Parkinson’s disease, has been offered by the Parkinson Foundation since 2019 to any person with a confirmed diagnosis of PD. The study is the first of its kind to return results at scale through live genetic counseling in English or Spanish. This enables participants and doctors to make more informed decisions about their care, including enrolling in gene-specific clinical trials.

Additional key findings from the PD GENEration study published in Brain include:

  • 7.7% of participants carried a GBA1 genetic mutation, 2.1% of participants carried a PRKN genetic mutation, and 2.4% of participants carried an LRRK2 genetic mutation. All participants were informed of their genetic status through the genetic counseling component of the program.
  • The positivity rate for a genetic variant is significantly higher for high-risk individuals. Those with early-onset PD, high-risk ancestry (such as Ashkenazi Jews, Spanish Basques, or North African Berbers), or a first-degree relative affected by the disease had a positivity rate of 18%. The positivity rate for people without one of these risk factors was almost 10%.

  • Many of these participants may qualify for precision medicine testing, demonstrating the feasibility and importance of widely offering genetic testing.

We did not expect the high rate of positivity for genetic mutations, namely almost 10% to have a positive result even without known genetic risk factors. Furthermore, the speed with which participants enrolled in PD GENEration is a testament to the interest of people with PD in obtaining data about their genetic status. Overall, the positivity rate and high interest in genotyping will hopefully translate into increased participation in observational studies and clinical trials for therapies targeting these genes, simplifying precision medicine clinical trials in PD.


Roy Alcalay, MD, MS, Associate Professor, Department of Neurology, Irving Medical Center, Columbia University

“PD GENEration is at the forefront of precision medicine and the potential for personalized therapies. In large part, this is because the Parkinson’s Foundation has recognized the importance of including genetic counseling in a research study that reveals genetic effects,” said Lola Cook, MS. , CGC, Department of Medicine and Molecular Genetics at Indiana University, who is the first author of Brain article and one of six genetic counselors participating in the study to date. “As we have seen from study enrollment numbers and research results, there is strong interest among people with PD to advance the research effort. This includes understanding the genetics of the disease, both broadly and individually. It is the idea that we all our part to move toward improved treatments and healing.”

PD GENEration continues into its next phase with the support of the Global Parkinson’s Genetics Program (GP2), a program of the Aligning Science Across Parkinson’s (ASAP) initiative. ASAP funding allows the Parkinson Foundation to accelerate the impact of the study by focusing on those historically underrepresented in research. Such improved broad-based recruitment reaches a wider and more diverse community in the United States, Canada and Latin America. The Parkinson’s Foundation aims to enroll an additional 8,000 participants, including 2,400 in Latin America, during the next phase of the study.

“PD GENEration is designed to be inclusive and accessible to all populations, with the goal of improving clinical outcomes for all. We are proud that the data we collected through PD GENEration reflect the largest and most diverse North American cohort tested ever—even though we hit our initial recruitment goal of 15,000 this spring, bigger things are on the horizon,” said James Beck, PhD, senior vice president and chief scientific officer of the Parkinson’s Foundation. “Our partnership with ASAP and the GP2 allows us to reach significantly more people, further increasing the diversity of participants. “Understanding the genetics shared by people with PD in different populations could reveal biological secrets of the disease, potentially leading to new treatments.”

Source:

Journal Reference:

Cook, L. et al. (2024). Parkinson’s disease variant detection and disclosure: PD GENEration, a North American study. Brain. doi.org/10.1186/s12916-024-03513-w

Common disease estimated genetic Parkinsons variants
bhanuprakash.cg
healthtost
  • Website

Related Posts

Who certifies Surinam as free malaria after decades of attempts

June 30, 2025

The new AI tool helps clinical doctors identify standards of brain activity associated with nine types of dementia

June 30, 2025

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

Leave A Reply Cancel Reply

Don't Miss
News

Who certifies Surinam as free malaria after decades of attempts

By healthtostJune 30, 20250

Today, Surinam became the first country in the Amazon region to obtain a malaria certification…

Does psychiatric drug kill creativity? Rejecting Van Gogh’s myth

June 30, 2025

The Role of Phytandrogens in BPH

June 30, 2025

What kind of professional community is most important to you? Exploring the benefits of SHA’s sex network – Alliance of Sexual Health

June 30, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment Understanding ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

Who certifies Surinam as free malaria after decades of attempts

June 30, 2025

Does psychiatric drug kill creativity? Rejecting Van Gogh’s myth

June 30, 2025

The Role of Phytandrogens in BPH

June 30, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.