Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

15 easy ways to get 20 grams of protein (Personal Trainer Guide)

June 29, 2025

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

How Barefoot Workout can make you stronger, more athletic and stunning in injuries

June 29, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

    June 29, 2025

    Expansion of genetic code to mammalian cells using pseuduridine -modified codons

    June 29, 2025

    Discover a Dimmer Genetic switch that controls fetal growth

    June 28, 2025

    Who Scientific Advisory Group for the origin of new pathogenic reports for Sars-Cov-2 Origins

    June 28, 2025

    Exploring nervous reactions to mental exhaustion in healthy adults

    June 27, 2025
  • Mental Health

    Which one is right for you? – Talkspace

    June 27, 2025

    Do alternative treatments for bipolar disorder work? Guide based on evidence (2025)

    June 26, 2025

    Data reveals both challenges and positive trends

    June 16, 2025

    How to choose the best yoga teacher training in Rishikesh

    June 14, 2025

    Stress is the most common mental health problem – here is how technology could help manage

    June 11, 2025
  • Men’s Health

    How Barefoot Workout can make you stronger, more athletic and stunning in injuries

    June 29, 2025

    How I turned the chatgpt to my personal nutrition coach and you can also

    June 29, 2025

    Total human care is here: Help men look and feel great now and forever

    June 28, 2025

    Why men ignore sleep apnea (and what they really cost them) – talking about men’s health

    June 28, 2025

    Lessons from a survivor for prostate cancer

    June 26, 2025
  • Women’s Health

    Books I have recently read – The Fitnessista

    June 29, 2025

    Does it support your aesthetic travel your body and mind? Guide

    June 28, 2025

    Eating for real immune support this winter

    June 27, 2025

    What does public health really mean

    June 27, 2025

    How long do you have to expand after MTF? A complete driver to expand – Vuvatech

    June 25, 2025
  • Skin Care

    Sunburn First Aid -7 common mistakes you will regret later

    June 29, 2025

    What is happening first? The step by step guide to build a routine of skin care

    June 28, 2025

    DIY Vitamin C Cucumber The Eye Serum

    June 27, 2025

    Tips for Summer skin care for your best skin

    June 26, 2025

    How a crisis of ingredients led to the best physical form of our deodorant stick

    June 24, 2025
  • Sexual Health

    Can Koles really get chlamydia?

    June 28, 2025

    Overward Visitor and Student Health Insurance in Australia for visa holders

    June 27, 2025

    Disassociation of the latest testosterone treatment lines

    June 27, 2025

    We always know that orgasms were good for you. Now there is proof.

    June 26, 2025

    Josh Duhamel gets testosterone replacement treatment at 52

    June 25, 2025
  • Pregnancy

    AI helps the couple capture after 19 years and 15 IVF attempts

    June 29, 2025

    7 signs your gut can be out of balance

    June 29, 2025

    Helping parents prepare for birth with calm and trust

    June 28, 2025

    Better screen limits for kids: Expert driver for parents

    June 28, 2025

    What is prenatal ability?

    June 27, 2025
  • Nutrition

    25 best vegan taco recipes that are healthy, easy and full of flavor

    June 29, 2025

    Episode 004: Trust your truth against all logic with Angela de la Agua

    June 28, 2025

    Benefits for the health of CoQ10 you should be aware

    June 27, 2025

    Creatine Completion in Menopause: What does science say?

    June 27, 2025

    GLP-1 Enhance the Smoothie recipes push for weight loss

    June 26, 2025
  • Fitness

    15 easy ways to get 20 grams of protein (Personal Trainer Guide)

    June 29, 2025

    Review of the Heat Index: an approach based on evidence

    June 28, 2025

    Bodybuilding Legend Charles Glass’ 5 Favorite Movements Hamstring

    June 27, 2025

    7 Best energy gels 2025, per runners and dieticians

    June 26, 2025

    Different types of training and fitness courses

    June 25, 2025
Healthtost
Home»News»First-in-class oral drug improves embryo implantation and pregnancy outcomes in IVF
News

First-in-class oral drug improves embryo implantation and pregnancy outcomes in IVF

healthtostBy healthtostJuly 8, 2024No Comments3 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
First In Class Oral Drug Improves Embryo Implantation And Pregnancy Outcomes In
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

New research has shown the effectiveness of a first-in-class oral, non-hormonal drug in increasing embryo implantation, pregnancy and live birth rates in infertile women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). The findings were presented today at ESHRE 40u The annual meeting in Amsterdam represents an important step towards the first therapeutic tool to increase the success of embryo implantation and the rate of live births.

Worldwide, one in six people of reproductive age experience infertility in their lifetime. Over 3 million IVF cycles are performed annually and yet, despite advanced IVF technologies, embryo implantation failure remains a significant challenge.

In response to this unmet need, researchers have revealed the promising findings of the Phase 2 clinical trial, OXOART2. This randomized, double-blind, placebo-controlled trial conducted at 28 centers in Europe evaluated OXO-001, a first-in-class oral drug that acts directly on the endometrium (inner lining of the uterus) to improve embryo implantation and of pregnancy rates.

The OXOLIFE study’s exploratory subgroup analyzed 96 women up to 40 years of age who underwent a single embryo transfer, 42 received placebo and 54 received a daily dose of OXO-001. Treatment began one menstrual cycle before the embryo transfer cycle and continued until five weeks after the transfer.

Statistically significant improvements were seen in biochemical pregnancy rates – an early detection of pregnancy – with rates of 75.9% in the OXO-001 group compared to 52.4% in the placebo group. Clinically relevant improvements were also seen in clinical pregnancy rates (fetal heart rate 5 weeks after transfer) and ongoing pregnancy rates (10 weeks after transfer), which is an absolute increase of +14.3 (50.0% for OXO- 001 vs. 35.7% for placebo) and +10.6 absolute increase (46.3% for OXO-001 vs. 35.7% for placebo) respectively.

Most importantly, there was an absolute increase of +6.9 in live birth rates (42.6% for OXO-001 vs. 35.7% for placebo).

Doctors and patients, we know that an absolute increase of more than 5 percentage points in ongoing pregnancy is considered clinically significant. We observed an increase higher than +9, giving renewed hope to patients and the scientific community. We look forward to advancing this promising treatment into the next phases of clinical development.”


Dr. Agnès Arbat, CEO and CMO of OXOLIFE

The incidence of adverse events was similar in both groups. The most common side effects were headaches, nausea, vomiting, gastrointestinal problems and dizziness, most of which were mild to moderate. Most importantly, at the six-month follow-up, the babies showed good growth with no differences with the placebo. Overall, OXO-001 was well tolerated, with high compliance rates.

Dr. Ignasi Canals, CSO of OXOLIFE adds: “We are excited by the results of this trial, which highlight the potential of OXO-001 to become the first therapeutic to increase embryo implantation success, with a non-hormonal drug that uses a new mechanism of action, acting directly on the endometrium”.

Professor Dr Karen Sermon, President of ESHRE, explains “Despite ongoing advances in ovarian stimulation, embryo manipulation and culture, the improvement in live birth rates in medically assisted reproduction has been incremental at best. A jump of almost 7% is very good news for our patients, and we hope this can be confirmed in larger groups of patients.”

The abstract of the study will be published today in Human Reproductionone of the leading reproductive medicine journals in the world.

Source:

European Society of Human Reproduction and Embryology

drug embryo Firstinclass implantation improves IVF Oral outcomes Pregnancy
bhanuprakash.cg
healthtost
  • Website

Related Posts

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

AI helps the couple capture after 19 years and 15 IVF attempts

June 29, 2025

Expansion of genetic code to mammalian cells using pseuduridine -modified codons

June 29, 2025

Leave A Reply Cancel Reply

Don't Miss
Fitness

15 easy ways to get 20 grams of protein (Personal Trainer Guide)

By healthtostJune 29, 20250

The acquisition of several proteins in your diet is vital to muscle repair, satiety and…

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

How Barefoot Workout can make you stronger, more athletic and stunning in injuries

June 29, 2025

Books I have recently read – The Fitnessista

June 29, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment Understanding ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

15 easy ways to get 20 grams of protein (Personal Trainer Guide)

June 29, 2025

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

How Barefoot Workout can make you stronger, more athletic and stunning in injuries

June 29, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.