A new study is exploring how epigenetic indicators-chemical modifications that affect the activity of generic genes help to predict the risk of developing cardiovascular diseases and guidance of personalized prevention strategies. The findings are particularly important, as the prevalence of significant cardietrian risk factors such as hypertension, diabetes and obesity continue to increase despite the progress of health care and treatment. This trend emphasizes the need for better timely detection and intervention.
The study is entitled “Multi-Graduate Scores for Cardiomatomal Risk Factors interact with demographic agents and health behaviors in older adults in the US” and are published in the magazine Epigenetic. It analyzes the PEGS, because there are a better record how the external environment shapes a person’s sensitivity to develop certain cardiomatomasal diseases and to adapt early prevention and intervention strategies on the basis of demographic elements of a person’s or demographic elements. The study examined PEGS’s relationship with the Body Mass Index (BMI), cholesterol levels and inflammation and how demographic agents (age, gender and education) and health behaviors (smoking, alcohol consumption and physical activity) affect these associations.
The researchers used data from the HRS health and retirement study (HRS) over 20,000 adults aged 50 years and over and DNA identification measurements from 4,104 respondents in the 2016 venous blood study (VBS). A total of 3,996 participants were included in the main analysis and 3,855 participants were included using sample weights.
They found that PEGS correlations with BMI, HDL cholesterol (good cholesterol) and triglycerides were stronger in young people, while BMI and HDL cholesterol compounds were more intense in female.
The study also found that people with high school training showed a stronger relationship between the mammals and the levels of C-reaction of protein (CRP), an inflammatory indicator associated with heart disease. He also found that the association between PEGS and HDL cholesterol was stronger among today’s smokers, suggesting that smoking can modify the effect of epigenetic indicators on cholesterol levels.
“These findings reinforce the idea that genetic risk is not stable life options and environmental factors play a critical role in shaping health results,” said Lisha Lin, PhD, chief writer and postdoctoral researcher at the Hinda Institute of Hinda. “By incorporating epigenetic indicators into risk assessment models, we can proceed with more personalized approaches to preventing and managing cardiovascular diseases.”
The study supports the clothespins as a valuable tool in precision medicine and emphasizes the importance of examining personal characteristics and behaviors in evaluating the risk of disease. Moving forward, researchers hope that these ideas will help develop more targeted interventions to help people with a higher risk for heart -wide diseases.
This study was partly supported by the National Institute for Alcohol Abuse and Alcoholism (NIAAA) with the R01 AA026687 grant number. and the National Institute of Heart, Spirit and Blood (NHLBI) with the R01 HL141292 grant number.
Source:
Magazine report:
Lynn, L., et al. (2025). Multi-epileptic ratings for cardiac risk factors interact with demographic agents and health behaviors in older US adults. Epigenetic. Doi.org/10.1080/15592294.2025.2469205.
