Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

Therapeutic restriction of carbohydrates for women’s health: metabolic and reproductive benefits

July 4, 2025

AI converts healthcare for faster, smarter emergency crises

July 4, 2025

Mental health in England is really worse – our research found that one in five adults is struggling

July 4, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    AI converts healthcare for faster, smarter emergency crises

    July 4, 2025

    Hepatitis E virus also attacks organs other than the liver, the study finds

    July 3, 2025

    Prenatal exposure to air pollution and climatic agents associated with adverse births in India

    July 3, 2025

    New Studies Questions The Catholic Benefits of Pet Property in Welfare

    July 2, 2025

    The combination of drugs shows a promise for the treatment of aggressive T-cell lymphomas

    July 2, 2025
  • Mental Health

    Mental health in England is really worse – our research found that one in five adults is struggling

    July 4, 2025

    Does psychiatric drug kill creativity? Rejecting Van Gogh’s myth

    June 30, 2025

    Which one is right for you? – Talkspace

    June 27, 2025

    Do alternative treatments for bipolar disorder work? Guide based on evidence (2025)

    June 26, 2025

    Data reveals both challenges and positive trends

    June 16, 2025
  • Men’s Health

    Can physical activity and exercise help my depression?

    July 4, 2025

    Nitty Gritty for Cancer and Prostate Control

    July 2, 2025

    Kettlebell Deadlifts Ultimate Guide for the form of strength and power

    July 1, 2025

    The Role of Phytandrogens in BPH

    June 30, 2025

    Just 150 minutes of exercise per week could prediabetes reversed

    June 30, 2025
  • Women’s Health

    Nightclub rituals that you should never skip

    July 3, 2025

    5 gender positions for mutual masturbation

    July 2, 2025

    Pregnancy Trichomonia Symptoms and treatments

    July 2, 2025

    Life after Hellp Syndrome – Hygiene

    July 1, 2025

    Top Home workouts for women 10 exercises to lose belly fat quickly

    June 30, 2025
  • Skin Care

    Improve Wellness with the Protocol of Misses Collection Protocol

    July 4, 2025

    Skin cycling and why your skin care is no longer working – oumere

    July 2, 2025

    Your sunscreen may fail you – here and dermatologists want you to know

    July 2, 2025

    Aging with grace how menopause can cause changes in the skin

    July 1, 2025

    Term Science: Why these tiny bottles are loud

    June 30, 2025
  • Sexual Health

    ‘It is difficult to overestimate the damage’

    July 2, 2025

    What kind of professional community is most important to you? Exploring the benefits of SHA’s sex network – Alliance of Sexual Health

    June 30, 2025

    Can Koles really get chlamydia?

    June 28, 2025

    Overward Visitor and Student Health Insurance in Australia for visa holders

    June 27, 2025

    Disassociation of the latest testosterone treatment lines

    June 27, 2025
  • Pregnancy

    How to teach your child to express anger in healthy ways

    July 4, 2025

    I really need an air cleaner in kindergarten?

    July 3, 2025

    The new study shows how mother’s birth effects

    July 3, 2025

    Naturally support your baby’s health

    July 1, 2025

    New Pink Magnesium Glucker, L-thean

    July 1, 2025
  • Nutrition

    Therapeutic restriction of carbohydrates for women’s health: metabolic and reproductive benefits

    July 4, 2025

    The amazingly simple trick that solved my meal programming headache

    July 3, 2025

    Canadian Ginseng and your metabolic health

    July 2, 2025

    15 minutes Korean beef tacos (family friendly + one Pan!)

    July 1, 2025

    25 best vegan taco recipes that are healthy, easy and full of flavor

    June 29, 2025
  • Fitness

    5 Simple Rules for Setting Objectives

    July 3, 2025

    12 safe and healthy ways to unleash the frustration

    July 3, 2025

    This 15 -minute yoga daily sequence will make you feel more flexible today

    July 2, 2025

    Popcorn with olive oil: Is it really healthy?

    July 2, 2025

    The success story of the AFPA Students – Dr. Nikki Letoya White

    June 30, 2025
Healthtost
Home»News»Bladder cancer detection at home: New diagnostic device
News

Bladder cancer detection at home: New diagnostic device

healthtostBy healthtostJanuary 23, 2025No Comments5 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
Bladder Cancer Detection At Home: New Diagnostic Device
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

The innovative diagnostic kit uses fluorescence-based detection to achieve 90% accuracy in detecting bladder cancer at an early stage.

Study: Diagnosis of early-stage bladder cancer through untreated point-of-care urine samples. Image credit: Orawan Pattarawimonchai/Shutterstock.com

In a recent study published in Nature Biomedical Engineeringa research team from the Republic of Korea investigated a new diagnostic system to detect early-stage bladder cancer using untreated urine samples.

The study showed that the device uses a two-layer system and suspended particles to send fluorescent signals, removing the need for sample preparation and making it a promising option for early detection of bladder cancer at home.

Background

Bladder cancer is one of the most common forms of cancer worldwide and is characterized by high rates of recurrence and progression. Early diagnosis, particularly during non-muscular infiltration, is crucial as it significantly improves survival outcomes.

However, current diagnostic methods such as cystoscopy and urine cytology are invasive, expensive and require specialized personnel. Furthermore, these approaches often lack sensitivity for early detection and are often affected by the heterogeneity of urine samples.

Several non-invasive, urine-based diagnostic methods, including molecular and enzymatic assays, have recently emerged. However, these methods often require sample pretreatment or fail to maintain accuracy in detecting biomarkers at low concentrations, especially in complex samples such as those with hematuria.

This unmet need for a sensitive, specific and user-friendly point-of-care diagnostic tool highlights the urgent need to develop accessible systems for the early detection and follow-up of bladder cancer.

The current study

In the present study, the team developed and validated a diagnostic device using a biphasic system containing buoyant organogel particles, which are produced by mixing low molecular weight compounds with organic media to detect bladder cancer at an early stage from urine samples that have not undergo treatment.

They named the assay the biological interference messenger-rectangular organelle with buoyancy lift, or BLOOM.

The system involved the enzymatic degradation of bigel membranes based on hyaluronic acid and containing organogel particles.

Upon degradation by urinary hyaluronidase, a biomarker for bladder cancer, the floating organogel particles will float on the oil layer, releasing solvochromic fluorescent dyes. Solvent chromic dyes change color when dissolved in different solvents.

The preparation of organopaste involved emulsifying Nile red dye, oleic acid, and 12-hydroxystearic acid in toluene, followed by cooling to form uniform, self-floating particles.

These particles were embedded in cross-linked hyaluronic acid hydrogels using glutaraldehyde. These bigel films were optimized for stability and sensitivity to low concentrations of hyaluronidase by adjusting the cross-linking density.

For the diagnostic application, the researchers added untreated urine samples to the bigel-coated surface, followed by a layer of dodecane oil to form the biphasic system. The fluorescence signal produced by the dissolved organogel in the oil phase was measured.

In addition, clinical validation of the device was conducted using 105 urine samples, including those from bladder cancer patients, subjects with other genitourinary diseases, and healthy controls.

The device was further tested using a low-cost, smartphone-based portable fluorescence reader. This minimized the need for laboratory infrastructure, allowing for potential home use.

Results

The study showed that the new diagnostic system effectively detected bladder cancer, including early-stage cases, with high sensitivity and specificity.

Using raw urine samples, the system achieved about 90% accuracy in a clinical trial involving 105 participants, which included bladder cancer patients, people with other genitourinary conditions, and healthy controls.

The device’s ability to detect hyaluronidase activity, a key biomarker of bladder cancer, was confirmed even in samples with complex compositions, such as those containing blood, from patients with hematuria.

In addition, the biphasic system was shown to be stable in maintaining signal purity by spatially separating the fluorescent signal from urinary components that could interfere with detection.

Furthermore, receiver operating characteristic curve analysis showed that the device demonstrated strong diagnostic performance for early-stage cancers. In addition, it reliably differentiated cases of non-muscle invasive bladder cancer (NMIBC) from healthy controls and other genitourinary diseases, which are commonly missed by existing diagnostic tools.

Compared to the Food and Drug Administration (FDA)-approved NMP22 or Nuclear Matrix Protein 22 test, the new system showed significantly higher sensitivity, especially for NMIBC and early-stage cases.

The device also overcame the challenges posed by hematuria and provided accurate results regardless of the blood content of the samples.

In addition, the integration of a smartphone-based fluorescence reader further validated the practicality of the system, enabling low-cost, consistent, and user-friendly testing.

These findings suggest that the BLOOM system is a promising tool for non-invasive, home-based screening and early detection of bladder cancer and could address critical gaps in existing diagnostic approaches.

conclusions

In summary, the research team developed a sensitive, specific, and user-friendly diagnostic tool for bladder cancer that allows early detection using unprocessed urine samples.

The two-phase system, combined with a smartphone-based fluorescence reader, offers an accessible and affordable solution for home testing.

Furthermore, addressing the limitations of existing methods, such as interference from hematuria and low biomarker sensitivity, this innovation represents a significant advance in non-invasive cancer diagnosis.

Journal Reference:

  • Keum, C., Yeom, H., Noh, TI, Yi, SY, Jin, S., Kim, C., Shim, JS, Yoon, SG, Kim, H., Lee, KH, Kang, SH, & Jeong, Y. (2024). Diagnosis of early-stage bladder cancer through untreated point-of-care urine samples. Nature Biomedical Engineering. doi:10.1038/s41551024012980.

bladder cancer detection device diagnostic Home
bhanuprakash.cg
healthtost
  • Website

Related Posts

AI converts healthcare for faster, smarter emergency crises

July 4, 2025

Hepatitis E virus also attacks organs other than the liver, the study finds

July 3, 2025

Prenatal exposure to air pollution and climatic agents associated with adverse births in India

July 3, 2025

Leave A Reply Cancel Reply

Don't Miss
Nutrition

Therapeutic restriction of carbohydrates for women’s health: metabolic and reproductive benefits

By healthtostJuly 4, 20250

Sarah Rice BSC. (Hons) Mcoptom (UK), MHP, NNP Generally, women are under -treated medical research,…

AI converts healthcare for faster, smarter emergency crises

July 4, 2025

Mental health in England is really worse – our research found that one in five adults is struggling

July 4, 2025

Can physical activity and exercise help my depression?

July 4, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Improve Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

Therapeutic restriction of carbohydrates for women’s health: metabolic and reproductive benefits

July 4, 2025

AI converts healthcare for faster, smarter emergency crises

July 4, 2025

Mental health in England is really worse – our research found that one in five adults is struggling

July 4, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.