Depression is known to be linked to the challenges of physical health, in all, from sleep disorder at an increased risk of cancer. Depression can also affect surgical results and postoperative costs, according to new findings in the study.
The research will be presented at the Clinical Conference of the American College of Surgeons (ACS) in Chicago, October 4-7.
Researchers at the University of Ohio in Columbus, Ohio and the Ohio Wexner University Medical Center found that patients with depression are less likely to have optimal surgical recovery. However, patients undergoing antidepressants were best attributed to multiple areas of surgical results.
Treating any diagnosis, especially as essential and destructive such as cancer, requires understanding other health and social risk factors. Understanding how mental health issues affect postoperative results can help create holistic and personalized treatment plans, predict and prevent complications and ultimately optimize patients’ results. ”
Erryk S. Katayama, Fourth Year Medical Student at the Medical College of the University of Ohio and lead author in the study
In this retrospective study, the researchers examined surveillance, epidemiology and final results to identify patients with colon cancer, hepatobicides and pancreatic cancers who were also diagnosed with depression 12 months before or after cancer. Through Medicare Part D data, the researchers also identified which patients had a prescription for antidepressants. The researchers then examined whether these patients had an “ideal” result after surgery, which meant that they did not report complications, had a long hospital stay, did not repeat in the hospital within 90 days or died within 90 days of surgery.
Of the 32,726 patients, 1,731 were also diagnosed with depression. Of these patients, 1,253 had received an antidepressant recipe and had no 478.
Basic findings
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Researchers found that patients with depression, whether or not patients were treated, had worse post-surgical recovery and higher costs. However, antidepressants reduced these results.
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While patients without depression went better overall, those with treatment who underwent treatment had better results, reduced stay lengths and readmission and lower mortality rates.
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Patients without depression also had the lowest cost of care ($ 17,551), followed by patients undergoing treatment (22,086, 7.3%increase) and non -treatment ($ 24,897, 10.2%increase) for depression.
Researchers have noted that previous studies have shown that patients with depression are more likely to be non -existent in medical treatment. “Treatment of this depression can help alleviate and treat depression and allow better compliance with self-care and treatment,” said Timothy M. Pawlik, MD, MPH, PhD, FACS, surgical oncologist at the University of Ohio Medical Center.
The inspiration for this research came from the Covid-19 pandemic, which brought an increased awareness of mental health.
“We started thinking about the consequences of mental health on surgical results and talking about health -related social needs,” Dr. Pawlik said. These factors included food insecurity, job insecurity and domestic violence.
Dr. Pawlik noted that the researchers used antidepressant recipes as an indicator of who did or did not receive treatment and did not examine whether a patient was in treatment or saw a psychiatrist, who is a restriction of the study. However, the results indicate the importance of sorting for depression before surgery “so that we can address the needs of our patients,” he said. The researchers also stressed the importance of patients not to ignore their mental health, especially when undergoing surgery.
“We ask our patients to take care of them because it helps them to be their best and the best place they can be,” Dr. Pawlik said.
Co-authors are Sidhaarth Iyer, BS. Selamawit Woldesenbet, Phd. and mujtaba khalil, mbbs.
Source:
Magazine report:
Katayama, E., et al. (2025) The impact of antidepressants on surgical results in patients with abdominal cancer and coexisting depression, scientific forum, Clinical Congress American College of Surgeons (ACS) 2025.