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Home»Men's Health»The brains of superagers resist age-related decline, study finds
Men's Health

The brains of superagers resist age-related decline, study finds

healthtostBy healthtostMay 11, 2024No Comments5 Mins Read
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The Brains Of Superagers Resist Age Related Decline, Study Finds
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In a recent study published in Journal of Neuroscienceresearchers examined the white matter of the brains of superagers, that is, people with exceptional cognitive performance, compared to typical older adults over a five-year period.

Despite non-significant differences in overall white matter health, the older adults showed better white matter microstructure, particularly in the frontal fibers, suggesting their resistance to age-related cognitive decline.

Study: Superagers resist the typical age-related white matter structural changes. Image credit: oneinchpunch / Shutterstock

Record

Aging is associated with structural and functional changes in the brain and with a decline in cognitive function. These declines, particularly in episodic memory, are often associated with neurodegenerative conditions such as Alzheimer’s disease.

However, a subset of older adults, called “superagers,” retain robust episodic memory comparable to healthy individuals decades younger, demonstrating how aging is possible without impaired episodic memory. Previous research has shown that superagers resist age-related changes in gray matter.

The scientists hypothesized that the elderly may also show preserved white matter integrity, particularly in vulnerable frontal brain regions, challenging the conventional pattern of white matter decline associated with aging.

About the study

This study aimed to understand the neural basis of the excellent memory of the elderly by examining the structural integrity of the white matter in their brains, which typically deteriorates with age.

The research assessed global white matter health and microstructural properties using diffusion imaging in older adults over 80 years of age, comparing them to typical older adults.

Participants were drawn from the Vallecas Project, a longitudinal study of 1213 Caucasian adults in Madrid, Spain. All participants lived in communities, were between 70 and 85 years old, had no psychiatric or neurological conditions, were expected to live for at least four years, and did not need help in their daily lives.

Of the subjects in this cohort, the elderly were defined as those aged 80 years or older with superior episodic memory compared to their age group. Specifically, their episodic memory was comparable to a person two to three decades younger.

MRI data were collected to assess the health and microstructure of the brain’s white matter. The researchers analyzed white matter volume and lesion volume, while the Fazekas scale was used to quantify white matter hyperintensities.

Diffusion-weighted images were processed, including motion correction and voxel-based diffusion map calculation. Path-based spatial statistics (TBSS) were used for group comparisons of diffusion parameters.

Longitudinal analyzes were conducted using linear mixed-effects models to assess changes over time. Statistical analyzes incorporated covariates such as age and total intracranial volume, with appropriate corrections for multiple comparisons.

The study used rigorous methodologies to compare white matter-related structural parameters in the elderly with those in the typical elderly, offering insights into the neural substrates of extraordinary memory aging.

Foundings

In the study, 64 older adults and a comparison group of 55 typical older adults were recruited from the Vallecas Project cohort, with no significant differences in age or gender between groups.

Superagers performed better on neuropsychological tests at baseline, but longitudinal assessments showed no significant differences in rates of cognitive decline other than a slower decline in animal fluency test scores among superagers.

Cross-sectional comparisons of white matter health revealed no significant differences in total white matter volume, volume of white matter lesions, or Fazekas scores between the two groups.

However, both groups showed a high prevalence of white matter lesions, with no significant differences in lesion severity.

Voxel-based analyzes of white matter microstructure showed higher fractional anisotropy (FA) and lower mean diffusion (MD) in older adults, particularly in frontal regions.

Over time, the older adults showed slower declines in the volume of white matter lesion than the comparison group, although this difference became nonsignificant after exclusion.

Furthermore, superagers showed slower declines in MD and FA over time than the comparison group in various white matter tracts, suggesting that white matter microstructure may be linked to resistance to age-related changes.

These findings highlight preserved white matter integrity in the elderly, potentially contributing to their superior cognitive abilities compared to typical elderly.

conclusions

Overall, the study highlights the importance of white matter health in cognitive aging.

While superagers and adults in the comparison group have similar healthy white matter based on volumetric and radiological measurements, regional analysis reveals more robust white matter microstructure among superagers, particularly in anterior brain regions and tracts with prolonged maturation.

This suggests a mechanism of resistance to age-related changes, possibly explaining the preservation of memory function in the elderly.

However, the authors acknowledge some limitations of the study, including the lack of assessment of other potential protective factors and the cross-sectional design.

Future research is needed to investigate the role of vascular health and other cardiovascular risk factors in white matter preservation. Longitudinal studies may shed light on the development of the hyperaging phenotype and its relationship to brain structural changes.

agerelated Brains decline finds resist study superagers
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