Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

Questions and answers about bladder cancer treatment

October 25, 2025

Shine with vitamin C, retinol & hydration – the natural wash

October 25, 2025

What every pregnant family should know about the ICU

October 25, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    Study reveals alarming rise in severe diverticulitis among Americans under 50

    October 25, 2025

    Discovery of the role of lingual and buccal cells in tooth development

    October 24, 2025

    Global study maps how trade and travel are fueling global spread of disease-carrying mosquitoes

    October 24, 2025

    The drug is showing impressive success in treating children with polymetastatic Ewing sarcoma

    October 23, 2025

    AI-driven eye screening aims to close diabetes vision gap in community clinics

    October 23, 2025
  • Mental Health

    Does TMS cause headaches or migraines? My experience + What helped

    October 23, 2025

    Our study of 267,000 children reveals the hidden burden of multiple developmental conditions

    October 17, 2025

    World Mental Health Day, 2025: Political repetitions make mental health harder

    October 9, 2025

    Beta Blockers: Why is celebrity checking to check this medicine?

    September 29, 2025

    The “anxiety economy” is thriving. But will companies benefit from our fears?

    September 25, 2025
  • Men’s Health

    Plank shoulder thrusts for a stronger core and better stability

    October 22, 2025

    A simple hand grip test can reveal your future obesity risk

    October 20, 2025

    Language barriers in health care have fallen — but not on the Internet, studies show

    October 20, 2025

    Looking for love in all the right places: Why the three-day rule is the matchmaker for the stars

    October 19, 2025

    GPS training in men’s eating disorders

    October 14, 2025
  • Women’s Health

    Questions and answers about bladder cancer treatment

    October 25, 2025

    The Business Accelerator for Health Coaches who want to finally make money online

    October 23, 2025

    A personalized guide for every woman

    October 22, 2025

    20bet Polska ᐉ Kasyno Przez Internet I Zakłady Sportowe 2025

    October 22, 2025

    Understanding the heredity of PCOS

    October 21, 2025
  • Skin Care

    Shine with vitamin C, retinol & hydration – the natural wash

    October 25, 2025

    Suma (Pfaffia paniculata) Extract in The Eye Serum — Release Update and Comments – OUMERE

    October 21, 2025

    Is Your Skin Care Really Working? (Here is the Spicy Truth 🌶️)

    October 21, 2025

    Mummy’s Mummy Makeover | About Facial Aesthetics

    October 20, 2025

    15 surprising facts about gluten-free beauty for sensitive skin: Scien

    October 20, 2025
  • Sexual Health

    Why you should switch to spermicide-free condoms

    October 24, 2025

    How to answer “Where do babies come from?” at every age

    October 23, 2025

    New cases of Mpox in California cause concern

    October 23, 2025

    More women are freezing their eggs for IVF later in life. Most will never use them.

    October 20, 2025

    Access to safe abortion services amid the COVID-19 pandemic < SRHM

    October 19, 2025
  • Pregnancy

    What every pregnant family should know about the ICU

    October 25, 2025

    Study finds caesarean section may increase risk of sleep disorders

    October 24, 2025

    A holistic approach to empowering women during birth

    October 23, 2025

    Back to work after maternity leave with Daphne Delvaux

    October 21, 2025

    Children’s music (that’s not bad)

    October 20, 2025
  • Nutrition

    Why Study Holistic Nutrition? The answer lies in our food system

    October 24, 2025

    The viral coffee drink we drink all winter

    October 23, 2025

    10 Collagen-Boosting Superfoods (and Ways to Get More Collagen) • Kath Eats

    October 23, 2025

    Can meat cause Parkinson’s disease?

    October 22, 2025

    Need a pest cleanse?

    October 21, 2025
  • Fitness

    Red Light Therapy at Home: Device Guide and Tips for Optimal Use

    October 25, 2025

    10 Healthy Things to Do When You’re Sick

    October 24, 2025

    Say goodbye to hip stiffness: 6 quick mobility routines

    October 23, 2025

    Total Gym F(all) Star Challenge – part 2

    October 22, 2025

    Power up your workout with pre-workout supplements

    October 21, 2025
Healthtost
Home»News»Mitochondrial dysfunction in blood -brain barrier can contribute to neuropsychiatric disease in 22qds
News

Mitochondrial dysfunction in blood -brain barrier can contribute to neuropsychiatric disease in 22qds

healthtostBy healthtostAugust 20, 2025No Comments4 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
Mitochondrial Dysfunction In Blood Brain Barrier Can Contribute To Neuropsychiatric
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

In a new study led by the University of Pennsylvania School of Veterinary Medicine (PENN VET) and the Philadelphia Children’s Hospital (CHOP), the researchers found that mitochondrial dysfunction in blood -brain barrier (BBB) can be found. The researchers have also shown that a category of cholesterol drugs approved by the FDA could possibly be redefined to treat this malfunction. These encouraging findings were published today in the magazine The translation medicine of science.

The BBB is a specialized vascular system that separates the brain from the rest of the body. The maintenance of the BBB is fundamental to the optimum brain function and the BBB disorders have been linked to multiple neurological disorders, ranging from autism and schizophrenia to neurodegenerative conditions, including multiple sclerosis and Alzheimer’s disease.

A notable feature of the BBB is increased mitochondrial content compared to peripheral endothelial cells, which form the inner lining of blood vessels. While mitochondrial dysfunction has been associated with neurodevelopmental and neurodegenerative disorders, few are known for its role in the BBB. To explore it in more detail, the researchers decided to focus on 22qds, also known as Digeorge Syndrome. This genetic condition, which includes six mitochondrial genes, increases the risk of neurodevelopmental and neurodegenerative diseases. Patients have a 25 times increased risk of developing psychosis and one in four people with this syndrome develop schizophrenia.

Chop has the largest clinic in the world dedicated to the care of children, adolescents and some adults with 22qds and a special team of Penn and Chop researchers is studying the situation as a window in the deepest mysteries of neurodevelopmental disease.

We have previously found that the BBB is at stake in 22qds, indicating that the interference between the brain and the periphery may be affected. With these findings, we have encountered the assumption that mitochondrial deficits contribute to the BBB malfunction in 22qds. ”


Jorge Iván Alvarez, PhD, Study Author, Associate Professor

“This study really demonstrates the power of cooperation,” said Study Author Stewart A. Anderson, MD, a research collaborator in the Department of Children and Adolescent Psychiatric and Behavioral Sciences in Chop and Deputy Director of the Brain Brain Chop/Penn Lifespan Institute. “By combining our corresponding expertise on mitochondrial function and BBB, we have made an important discovery that can essentially help people with 22qds.”

The researchers have actually found damage, indicating a “leak” BBB, using a combination of human -abductors of microvascular endothelial brain cells derived from 22qds of stem cell cells and 22qds BBB intracetic cells.

Perhaps more exciting, the researchers found that the treatment with Bezafibrate pharmacy, a cholesterol drug that is also an actuator of mitochondrial production and turnover, can enhance BBB function both in the stem cell system and the 22QDs. The treatment in the preclinical model also corrected the deficit in social memory, an abnormality associated with the malfunction of the BBB as well as schizophrenia. These findings indicate that this category of drugs could potentially be repositioned if the findings are confirmed in clinical trials. While 22qds was the focus of this study, Dr. Anderson and Alvarez and their groups believe that the findings can have an impact on the role of the role of mitochondrial dysfunction in BBB in other neuropsychiatric conditions, including the development of psychosis outside the 22qds framework.

This study was supported by the Neuropsochiatry Research research program of the Uytengsu-Hamilton 22Q11 of the Mother and Child Research Research Institute (MCHRI) at Stanford UH22QEXTFY22-03. The grant of the National Institutes of Health (NIH) at the Institute of Translation Medicine and therapeutic (ITMAT) and the Tapitmat (Tapitmat) program of the University of Pennsylvania NCATS 5Ul1TR001878-04. NIH grants R01MH134797-01, R01MH134893-01, R01MH110185-03, R01MH066912 and R37NS048471; NIH -National Institute of Nih Grant F32MH125600 brain Institute; The Penrose family; The Howard Hughes Medical Institute. The Graduate Foundation Foundation Family Foundation of Blavatnik. The great hardening of Canada -HERDI PLAND SERVICE? and the brain and behavior research institution.

Source:

Philadelphia Children’s Hospital

Magazine report:

Crockett, am, et al. (2025) Bezafibrate improves mitochondrial function, the integrity of the blood -brain barrier and social deficits in models of 22q11.2 deletion syndrome. The translation medicine of science. doi.org/10.1126/scitranslmed.ads2116.

22qds barrier blood brain Contribute disease Dysfunction mitochondrial neuropsychiatric
bhanuprakash.cg
healthtost
  • Website

Related Posts

Study reveals alarming rise in severe diverticulitis among Americans under 50

October 25, 2025

Discovery of the role of lingual and buccal cells in tooth development

October 24, 2025

Global study maps how trade and travel are fueling global spread of disease-carrying mosquitoes

October 24, 2025

Leave A Reply Cancel Reply

Don't Miss
Women's Health

Questions and answers about bladder cancer treatment

By healthtostOctober 25, 20250

Bladder cancer (UBC) is cancer that starts in the cells that line the inside of…

Shine with vitamin C, retinol & hydration – the natural wash

October 25, 2025

What every pregnant family should know about the ICU

October 25, 2025

Red Light Therapy at Home: Device Guide and Tips for Optimal Use

October 25, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Improve Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals risk routine sex sexual Skin study Therapy Tips Top Training Treatment Understanding ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

Questions and answers about bladder cancer treatment

October 25, 2025

Shine with vitamin C, retinol & hydration – the natural wash

October 25, 2025

What every pregnant family should know about the ICU

October 25, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.