Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

Just 150 minutes of exercise per week could prediabetes reversed

June 30, 2025

Top Home workouts for women 10 exercises to lose belly fat quickly

June 30, 2025

Term Science: Why these tiny bottles are loud

June 30, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

    June 29, 2025

    Expansion of genetic code to mammalian cells using pseuduridine -modified codons

    June 29, 2025

    Discover a Dimmer Genetic switch that controls fetal growth

    June 28, 2025

    Who Scientific Advisory Group for the origin of new pathogenic reports for Sars-Cov-2 Origins

    June 28, 2025

    Exploring nervous reactions to mental exhaustion in healthy adults

    June 27, 2025
  • Mental Health

    Which one is right for you? – Talkspace

    June 27, 2025

    Do alternative treatments for bipolar disorder work? Guide based on evidence (2025)

    June 26, 2025

    Data reveals both challenges and positive trends

    June 16, 2025

    How to choose the best yoga teacher training in Rishikesh

    June 14, 2025

    Stress is the most common mental health problem – here is how technology could help manage

    June 11, 2025
  • Men’s Health

    Just 150 minutes of exercise per week could prediabetes reversed

    June 30, 2025

    How Barefoot Workout can make you stronger, more athletic and stunning in injuries

    June 29, 2025

    How I turned the chatgpt to my personal nutrition coach and you can also

    June 29, 2025

    Total human care is here: Help men look and feel great now and forever

    June 28, 2025

    Why men ignore sleep apnea (and what they really cost them) – talking about men’s health

    June 28, 2025
  • Women’s Health

    Top Home workouts for women 10 exercises to lose belly fat quickly

    June 30, 2025

    Books I have recently read – The Fitnessista

    June 29, 2025

    Does it support your aesthetic travel your body and mind? Guide

    June 28, 2025

    Eating for real immune support this winter

    June 27, 2025

    What does public health really mean

    June 27, 2025
  • Skin Care

    Term Science: Why these tiny bottles are loud

    June 30, 2025

    Sunburn First Aid -7 common mistakes you will regret later

    June 29, 2025

    What is happening first? The step by step guide to build a routine of skin care

    June 28, 2025

    DIY Vitamin C Cucumber The Eye Serum

    June 27, 2025

    Tips for Summer skin care for your best skin

    June 26, 2025
  • Sexual Health

    Can Koles really get chlamydia?

    June 28, 2025

    Overward Visitor and Student Health Insurance in Australia for visa holders

    June 27, 2025

    Disassociation of the latest testosterone treatment lines

    June 27, 2025

    We always know that orgasms were good for you. Now there is proof.

    June 26, 2025

    Josh Duhamel gets testosterone replacement treatment at 52

    June 25, 2025
  • Pregnancy

    AI helps the couple capture after 19 years and 15 IVF attempts

    June 29, 2025

    7 signs your gut can be out of balance

    June 29, 2025

    Helping parents prepare for birth with calm and trust

    June 28, 2025

    Better screen limits for kids: Expert driver for parents

    June 28, 2025

    What is prenatal ability?

    June 27, 2025
  • Nutrition

    25 best vegan taco recipes that are healthy, easy and full of flavor

    June 29, 2025

    Episode 004: Trust your truth against all logic with Angela de la Agua

    June 28, 2025

    Benefits for the health of CoQ10 you should be aware

    June 27, 2025

    Creatine Completion in Menopause: What does science say?

    June 27, 2025

    GLP-1 Enhance the Smoothie recipes push for weight loss

    June 26, 2025
  • Fitness

    15 easy ways to get 20 grams of protein (Personal Trainer Guide)

    June 29, 2025

    Review of the Heat Index: an approach based on evidence

    June 28, 2025

    Bodybuilding Legend Charles Glass’ 5 Favorite Movements Hamstring

    June 27, 2025

    7 Best energy gels 2025, per runners and dieticians

    June 26, 2025

    Different types of training and fitness courses

    June 25, 2025
Healthtost
Home»News»Immune cell inflammation may be responsible for some severe symptoms in lysosomal storage diseases
News

Immune cell inflammation may be responsible for some severe symptoms in lysosomal storage diseases

healthtostBy healthtostJuly 12, 2024No Comments3 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
Immune Cell Inflammation May Be Responsible For Some Severe Symptoms
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

Researchers at The Hospital for Sick Children (SickKids) have discovered that inflammation in an immune cell may be partly responsible for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs).

LSD affects approximately one in 7,700 live births worldwide. Children with the condition usually present at a young age with progressive neurodegeneration. Many children with LSD die prematurely, and current treatments focus on symptom management.

Until now, the role of macrophages in the immune system and LSDs was not well known, but new research published in Nature Cell Biology led by Dr. Spencer Freeman, scientist in the Cell Biology program, Ruiqi Cai, senior postdoctoral fellow and first author of the study, and Ori Scott, Transitional Clinical Scientist in the Cell Biology program and Staff Physician in the Department of Immunology and Allergy, found that inflammation of macrophages may contribute to LSD symptoms.

Macrophage cells take in and digest a large amount of nutrients to help the immune system function normally. To break down and recycle these nutrients, cells rely on tiny organelles called lysosomes. When functional, a lysosome can break down large sugars into small sugars, which are then used as a source of energy. In LSDs, these macrophage lysosomes swell and fill with waste.

In publishing these findings, Freeman, Cai and Scott share how LSDs affect the immune system and how reducing inflammation could potentially improve or prevent symptoms in children on LSD.

What is different about macrophages in LSD patients?

In LSD macrophages, the swollen lysosomes try to avoid opening and spilling their contents – which would cause the cell to die. To do this, lysosomes open a channel that moves sodium out of the lysosomes, followed by water, to keep them smaller. This creates a message: the lysosome and the cell are stressed.

The stressed macrophages then send an “SOS” signal by releasing a substance called MCP-1 (monocyte chemoattractant protein 1) that tells other macrophages: “please come help”. As a result, many more macrophages move into the tissue. When there are too many macrophages in a tissue and they all secrete MCP-1, this can cause inflammation and tissue damage.

How can your findings help LSD patients?

Our findings suggest that blocking sodium channel or MCP-1 receptor in macrophages could reduce inflammation and tissue damage in LSDs. There are already drugs that target these molecules, some of which are used for other inflammatory conditions such as rheumatoid arthritis. We plan to test these drugs in preclinical models and hope to translate the results into clinical trials for LSD patients.

By studying what causes severe symptoms in children with LSD, we can identify better treatments for patients affected by these devastating conditions.

What are the next steps for your research?

We continue to investigate how the lysosome regulates macrophage function and inflammation in LSDs and other conditions, including neurodegenerative diseases. We hope that by understanding the molecular mechanisms of lysosomal dysfunction and inflammation we can identify new targets for drug development and improve the quality of life of patients with LSD and other related conditions such as Parkinson’s disease.

When we study people with rare pediatric conditions, the benefits go beyond those individuals and their families and extend to everyone, improving our knowledge of the complexity of human biology.

This research was funded by the Canadian Institutes of Health Research (CIHR), the German Research Foundation, Hightech Agenda Bavaria, the European Research Council and the Metropolitan University of Toronto.

Source:

The Hospital for Sick Children

Journal Reference:

Cai, R., et al. (2024). Lysosomal stress sensing allows control of TFEB responses in macrophages. Nature Cell Biology. doi.org/10.1038/s41556-024-01459-y.

cell diseases immune inflammation lysosomal responsible severe Storage Symptoms
bhanuprakash.cg
healthtost
  • Website

Related Posts

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

Expansion of genetic code to mammalian cells using pseuduridine -modified codons

June 29, 2025

Discover a Dimmer Genetic switch that controls fetal growth

June 28, 2025

Leave A Reply Cancel Reply

Don't Miss
Men's Health

Just 150 minutes of exercise per week could prediabetes reversed

By healthtostJune 30, 20250

A new study finds that staying active for just more than two hours a week…

Top Home workouts for women 10 exercises to lose belly fat quickly

June 30, 2025

Term Science: Why these tiny bottles are loud

June 30, 2025

15 easy ways to get 20 grams of protein (Personal Trainer Guide)

June 29, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment Understanding ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

Just 150 minutes of exercise per week could prediabetes reversed

June 30, 2025

Top Home workouts for women 10 exercises to lose belly fat quickly

June 30, 2025

Term Science: Why these tiny bottles are loud

June 30, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.