Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

The success story of the AFPA Students – Dr. Nikki Letoya White

June 30, 2025

The new AI tool helps clinical doctors identify standards of brain activity associated with nine types of dementia

June 30, 2025

Just 150 minutes of exercise per week could prediabetes reversed

June 30, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    The new AI tool helps clinical doctors identify standards of brain activity associated with nine types of dementia

    June 30, 2025

    Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

    June 29, 2025

    Expansion of genetic code to mammalian cells using pseuduridine -modified codons

    June 29, 2025

    Discover a Dimmer Genetic switch that controls fetal growth

    June 28, 2025

    Who Scientific Advisory Group for the origin of new pathogenic reports for Sars-Cov-2 Origins

    June 28, 2025
  • Mental Health

    Which one is right for you? – Talkspace

    June 27, 2025

    Do alternative treatments for bipolar disorder work? Guide based on evidence (2025)

    June 26, 2025

    Data reveals both challenges and positive trends

    June 16, 2025

    How to choose the best yoga teacher training in Rishikesh

    June 14, 2025

    Stress is the most common mental health problem – here is how technology could help manage

    June 11, 2025
  • Men’s Health

    Just 150 minutes of exercise per week could prediabetes reversed

    June 30, 2025

    How Barefoot Workout can make you stronger, more athletic and stunning in injuries

    June 29, 2025

    How I turned the chatgpt to my personal nutrition coach and you can also

    June 29, 2025

    Total human care is here: Help men look and feel great now and forever

    June 28, 2025

    Why men ignore sleep apnea (and what they really cost them) – talking about men’s health

    June 28, 2025
  • Women’s Health

    Top Home workouts for women 10 exercises to lose belly fat quickly

    June 30, 2025

    Books I have recently read – The Fitnessista

    June 29, 2025

    Does it support your aesthetic travel your body and mind? Guide

    June 28, 2025

    Eating for real immune support this winter

    June 27, 2025

    What does public health really mean

    June 27, 2025
  • Skin Care

    Term Science: Why these tiny bottles are loud

    June 30, 2025

    Sunburn First Aid -7 common mistakes you will regret later

    June 29, 2025

    What is happening first? The step by step guide to build a routine of skin care

    June 28, 2025

    DIY Vitamin C Cucumber The Eye Serum

    June 27, 2025

    Tips for Summer skin care for your best skin

    June 26, 2025
  • Sexual Health

    Can Koles really get chlamydia?

    June 28, 2025

    Overward Visitor and Student Health Insurance in Australia for visa holders

    June 27, 2025

    Disassociation of the latest testosterone treatment lines

    June 27, 2025

    We always know that orgasms were good for you. Now there is proof.

    June 26, 2025

    Josh Duhamel gets testosterone replacement treatment at 52

    June 25, 2025
  • Pregnancy

    AI helps the couple capture after 19 years and 15 IVF attempts

    June 29, 2025

    7 signs your gut can be out of balance

    June 29, 2025

    Helping parents prepare for birth with calm and trust

    June 28, 2025

    Better screen limits for kids: Expert driver for parents

    June 28, 2025

    What is prenatal ability?

    June 27, 2025
  • Nutrition

    25 best vegan taco recipes that are healthy, easy and full of flavor

    June 29, 2025

    Episode 004: Trust your truth against all logic with Angela de la Agua

    June 28, 2025

    Benefits for the health of CoQ10 you should be aware

    June 27, 2025

    Creatine Completion in Menopause: What does science say?

    June 27, 2025

    GLP-1 Enhance the Smoothie recipes push for weight loss

    June 26, 2025
  • Fitness

    The success story of the AFPA Students – Dr. Nikki Letoya White

    June 30, 2025

    15 easy ways to get 20 grams of protein (Personal Trainer Guide)

    June 29, 2025

    Review of the Heat Index: an approach based on evidence

    June 28, 2025

    Bodybuilding Legend Charles Glass’ 5 Favorite Movements Hamstring

    June 27, 2025

    7 Best energy gels 2025, per runners and dieticians

    June 26, 2025
Healthtost
Home»News»Association of genetically extended PDE5 inhibition with measures of fertility, sexual behavior and well-being
News

Association of genetically extended PDE5 inhibition with measures of fertility, sexual behavior and well-being

healthtostBy healthtostDecember 14, 2023No Comments4 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
Association Of Genetically Extended Pde5 Inhibition With Measures Of Fertility,
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

In a recent study published in BMJresearchers performed a randomization analysis of two Mendelian samples to investigate the associations between genetically appreciable (via a surrogate biomarker) suppression of phosphodiesterase 5 (PDE5), a recognized pharmacologic target for erectile dysfunction, fertility, subjective well-being, and sexual behavior.

Study: A drug target for erectile dysfunction that helps improve fertility, sexual activity and well-being: a Mendelian randomized study. Image credit: bangoland/Shutterstock.com

Record

Fertility is declining in many nations, and improving sexual performance can help reverse this trend. Erectile dysfunction and pulmonary hypertension are usually treated with phosphodiesterase-5 inhibitory agents such as vardenafil, sildenafil, avanafil and tadalafil. Increased levels of cyclic guanosine monophosphate (GMP) enhance vascular smooth muscle relaxation and vasodilation, enhancing penile blood flow and ventilation-perfusion correspondence through PDE5 inhibition. Randomized clinical trials provide critical data on the therapeutic efficacy, safety, and side effects of drugs. However, short-term use does not allow long-term effects to be investigated.

Further research is needed to improve understanding of the effects of PDE-5 inhibition on fertility and well-being, as PDE-5 inhibitors are available over-the-counter in countries such as the United Kingdom (UK). Mendelian randomization is an alternative epidemiologic strategy to improve causal inference in observational research designs that allows genetic variants that predict a particular trait to be randomly assigned at conception.

About the study

In the present study, researchers evaluated the effects of phosphodiesterase-5 on fertility, subjective well-being and sexual behavior in men.

The study analyzed summary data on genomic associations among European men from the International Blood Pressure Consortium (n=757,601) and the UK Biobank (n=211,840) datasets. The study intervention was genetically discounted phosphodiesterase-5 inhibition. Outcome measures were number of sexual partners, number of children born, probability of never having had sex, and subjective well-being.

The researchers performed cis-mendelian randomization to assess the effects of genome-wide phosphodiesterase-5 inhibition on fertility, sexual behavior, and subjective well-being. The team analyzed mostly men, with secondary studies conducted in women to investigate whether the established relationships were associated with the presence of a penis (phosphodiesterase-5 inhibition can help with penile erection).

The team derived estimates of the relationship between blood pressure and variations from genome-wide association analyzes associated with diastolic blood pressure. Genome-wide association studies (GWAS) of diastolic blood pressure included 757,601 European participants of both sexes from 77 cohorts in the UK Biobank and the International Blood Pressure Consortium. The researchers adjusted the groups for age, body mass index (BMI) and sex, and corrected the UK Biobank sample for drug use. The same study provided genome-wide association estimates for diastolic blood pressure to perform a sensitivity analysis. The Elsworth United Kingdom Biobank Genome Association Survey (n=209,872) provided variation data on the number of offspring born.

Results

The researchers identified five genetic variants that could suppress phosphodiesterase-5. The basic version calculated a value of 0.2 mmHg lower diastolic blood pressure and obtained an F statistic of 26, indicating a minimal possibility of instrument bias. Positive control studies revealed a Mendelian randomization association between genomic phosphodiesterase-5 inhibition and pulmonary hypertension and erectile dysfunction.

Genetically discounted phosphodiesterase-5 inhibition was associated with males having 0.3 more children (adjusted false discovery rate) when modeled on the estimated diastolic blood pressure-lowering effect of 100.0 mg sildenafil (5.50 mm Hg) . The relationship, however, was not detected in women. In the localization analysis, the second research hypothesis, that is, a causal genetic variant for the first trait but not for the second trait, showed a probability of 91%, indicating that the statistical power of the findings was insufficient to determine whether the observed association was due to the presence of common causative variants or variants in linkage disequilibrium (LD, i.e. horizontal pleiotropy).

The researchers found no association between genomic phosphodiesterase-5 inhibition and male sexual partners, likelihood of intercourse, or self-reported well-being. The findings of sensitivity studies using systolic blood pressure and Mendelian randomization estimates were comparable.

The study also found no association between genetically estimated phosphodiesterase inhibition and the number of male offspring, except for a weaker association with diastolic blood pressure. After controlling for any pleiotropic bias with cis-mendelian randomization, the main study findings remained similar, indicating that genetic variants may not explain clinically relevant variation in health-related outcomes.

conclusion

Further research is needed to validate this and to avoid encouraging the use of PDE5 inhibitors, which may have adverse effects such as vision loss. Improper use can also lead to hypotension and improperly timed erection. PDE5 inhibitors may increase fertility in male patients with erectile dysfunction.

Association behavior extended fertility genetically inhibition measures PDE5 sexual wellbeing
bhanuprakash.cg
healthtost
  • Website

Related Posts

The new AI tool helps clinical doctors identify standards of brain activity associated with nine types of dementia

June 30, 2025

Organ chip technology accurately predicts chemotherapy response to patients with esophageal adenocarcinoma

June 29, 2025

Expansion of genetic code to mammalian cells using pseuduridine -modified codons

June 29, 2025

Leave A Reply Cancel Reply

Don't Miss
Fitness

The success story of the AFPA Students – Dr. Nikki Letoya White

By healthtostJune 30, 20250

During the last 31+ years, the AFPA has certified over 130,000 health, nutrition and exercise…

The new AI tool helps clinical doctors identify standards of brain activity associated with nine types of dementia

June 30, 2025

Just 150 minutes of exercise per week could prediabetes reversed

June 30, 2025

Top Home workouts for women 10 exercises to lose belly fat quickly

June 30, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment Understanding ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

The success story of the AFPA Students – Dr. Nikki Letoya White

June 30, 2025

The new AI tool helps clinical doctors identify standards of brain activity associated with nine types of dementia

June 30, 2025

Just 150 minutes of exercise per week could prediabetes reversed

June 30, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.