Close Menu
Healthtost
  • News
  • Mental Health
  • Men’s Health
  • Women’s Health
  • Skin Care
  • Sexual Health
  • Pregnancy
  • Nutrition
  • Fitness
What's Hot

30 minutes Kettlebell Core Workouts to strengthen your abdomen

June 9, 2025

Semaglutide for Weight Loss – Summer Safety and Side Effects Guide

June 9, 2025

Teenagers and sexual education during the Covid-19 pandemic and beyond

June 9, 2025
Facebook X (Twitter) Instagram
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms and Conditions
  • Disclaimer
Facebook X (Twitter) Instagram
Healthtost
SUBSCRIBE
  • News

    AI model detects brain tumors with high precision using epigenetic fingerprints

    June 8, 2025

    The new study warns long -term risks from germ transplants

    June 8, 2025

    Self-collection tests could be a solution to increase access to cervical cancer control

    June 7, 2025

    Preeclampsia associated with long -term brave disbelief and worsening the effects of stroke

    June 7, 2025

    In Axing’s MRNA contract, Trump delivers another blow to US bio -security, former officials say

    June 6, 2025
  • Mental Health

    Heart attack or panic attack? Why do young people call ambulances for non -managed stress

    June 7, 2025

    My journey, my development, my truth – uninterrupted

    June 6, 2025

    Why I am fighting for mental health change

    June 3, 2025

    Girls with painful periods are twice as high as their peers to have symptoms of anxiety or depression

    June 2, 2025

    Does psychiatric drug kill creativity? Rejecting Van Gogh’s myth

    May 29, 2025
  • Men’s Health

    30 minutes Kettlebell Core Workouts to strengthen your abdomen

    June 9, 2025

    Scientists identify genetic indications that connect air pollution to neurodegeneration

    June 7, 2025

    Do you want a stronger back? This Powerlifter’s secret weapon is a secret weapon

    June 7, 2025

    Chains, bands and greater profits: Guide to deal with resistance

    June 6, 2025

    Phil Stutz, True Magic & Healing Mankind: Useful tools for today’s World – Part 2: Universe 1 and Universe 2

    June 6, 2025
  • Women’s Health

    Making the connection between collagen and recovery from exercise

    June 8, 2025

    Alice Connors for purpose and progress

    June 4, 2025

    8 teenagers of vitamins must actually get

    June 4, 2025

    Reasons for frequent urination

    June 3, 2025

    Life with myalgian encephalomyelitis/chronic fatigue syndrome

    June 3, 2025
  • Skin Care

    Semaglutide for Weight Loss – Summer Safety and Side Effects Guide

    June 9, 2025

    10 signs it’s time to see an acne expert

    June 8, 2025

    11 Important facts for Botox Botox hood

    June 7, 2025

    Liposcopy: Is it right for you?

    June 7, 2025

    Ideas for father’s day and beyond

    June 4, 2025
  • Sexual Health

    Teenagers and sexual education during the Covid-19 pandemic and beyond

    June 9, 2025

    The odd rise of cases of syphilis to heterosexual men in the UK

    June 8, 2025

    The Role of Certified LGBTQ Certified Sexual Therapist – Sexual Health Alliance

    June 7, 2025

    How Pride paved the way for sexual well -being

    June 5, 2025

    Best male masturbation positions Female

    June 4, 2025
  • Pregnancy

    Love in Melbourne Australia – Tiffany Rose Maternity Blog UK

    June 8, 2025

    How to remain calm with high blood pressure during pregnancy?

    June 7, 2025

    Pink Stork’s flagship product – as shown in “Empowered by Meg Ryan”

    June 7, 2025

    You don’t have to know everything – only that before birth

    June 6, 2025

    Top 100 Names of Girls 2024

    June 5, 2025
  • Nutrition

    The busy mom’s driver for intestinal-brain connection

    June 7, 2025

    Healthy Banana Bread (Child Approved) Sarah Remat

    June 6, 2025

    The secret to the loss of persistent belly fat by registered dieticians

    June 5, 2025

    Why are you always tired and what to do

    June 5, 2025

    20 herbal and wonderful recipes with appetizers

    June 4, 2025
  • Fitness

    Creamy all the toast Avocado bagel (easy, salty breakfast!)

    June 8, 2025

    Men’s Health Month: Dealing longevity vacuum

    June 7, 2025

    Best 12 biceps exercises ranked: build larger and stronger weapons

    June 6, 2025

    Próximamente el 10 de junio: 25 minutes of train de Joel Freeman

    June 5, 2025

    The best weight counter to add to your home gym in your 2025

    June 5, 2025
Healthtost
Home»News»New computational pipeline revolutionizes personalized cancer vaccine design
News

New computational pipeline revolutionizes personalized cancer vaccine design

healthtostBy healthtostOctober 12, 2024No Comments4 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
New Computational Pipeline Revolutionizes Personalized Cancer Vaccine Design
Share
Facebook Twitter LinkedIn Pinterest WhatsApp Email

Ludwig Cancer Research scientists have developed a complete computational pipeline that integrates multiple molecular and genetic analyzes of tumors and the specific molecular targets of T cells and leverages artificial intelligence algorithms to use its results to design personalized cancer vaccines for patients.

The design, validation, and benchmarking of this computational suite, NeoDisc, are detailed in the current issue of Biotechnology of nature in a paper led by Florian Huber and Michal Bassani-Sternberg of the Lausanne Branch of the Ludwig Institute for Cancer Research.

“NeoDisc provides unique insights into the immunobiology of tumors and the mechanisms by which they evade targeting by cytotoxic T cells of the immune system,” said Bassani-Sternberg. “These insights are invaluable for designing personalized immunotherapies, and the analytical and computational pipeline at the heart of NeoDisc is already being used here in Lausanne for clinical trials of personalized cancer vaccines and cell therapies.

Many types of cancer harbor multiple random mutations that should make them more visible to the immune system. Such mutations create aberrant proteins that cells, even cancerous ones, are programmed to cut into small pieces – known as peptides – and “present” as antigens to invite an attack by patrolling T cells.

The wide variety of these “neoantigens” is one of the reasons why patients respond so variably to immunotherapies. On the other hand, neoantigens can be harnessed to develop vaccines and other types of immunotherapies tailored to uniquely target each patient’s tumors. Personalized treatments of this kind are now being developed by researchers around the world.

Such efforts are technically challenging because not all neoantigens are recognized by a given patient’s T cells, and even many that are recognized fail to elicit a sufficiently strong T cell attack. Therefore, one approach to designing personalized vaccines and cell therapies involves identifying neoantigens that are most likely to elicit a vigorous T cell attack.

This requires sophisticated, large-scale analyzes of mutations that create potential neoantigens, the molecular scaffold (known as HLA molecules) that presents them to T cells, and the molecular features that enable recognition by T cell receptors. Bassani-Sternberg is among the pioneers of this field, a high-tech marriage of biochemical and large-scale computational analysis known as “immunopeptidomics.”

The design of personalized immunotherapies is also aided by the genomic analysis of both tumor and blood cells that represent the patient’s healthy genome, the large-scale analysis of gene expression known as “transcriptomics” as well as the sensitive analysis of what is called immunopeptide mass spectrometry . Until now, however, these powerful technologies have never been integrated into a single computational pipeline to predict which neoantigens found in a patient’s tumors should be used as vaccines or otherwise used for personalized immunotherapies.

Furthermore, neoantigens are not the only type of antigens available for immunotherapeutic targeting. Cancer cells also misexpress pieces of normally noncoding DNA, genes normally expressed only during development, other aberrantly expressed gene products, and viral antigens, in cases of virus-induced tumors—all of which can trigger an immune attack.

“NeoDisc can detect all these different types of tumor-specific antigens along with neoantigens, apply machine learning and rule-based algorithms to prioritize those most likely to elicit a T-cell response, and then use this information to design a personalized cancer vaccine. relevant patient,” Huber said.

NeoDisc additionally ranks the potential antigens it detects and creates visualizations of tumor cell heterogeneity within tumors.

“Notably, NeoDisc can also detect potential defects in the antigen presentation machinery, alerting vaccine designers and clinicians to a key immune evasion mechanism in tumors that can compromise the efficacy of immunotherapy,” said Bassani-Sternberg. “This can help them select patients for clinical studies who are likely to benefit from personalized immunotherapy, a skill that is also of great importance for optimizing patient care.”

The researchers further show in their study that NeoDisc provides a more accurate selection of effective cancer antigens for vaccines and cell therapies than other computational tools currently used for this purpose.

To further improve NeoDisc’s accuracy, researchers will continue to feed data obtained from a variety of tumors and incorporate additional machine learning algorithms into the software suite to advance its training and improve its predictive accuracy.

Source:

Ludwig Institute for Cancer Research

Journal Reference:

Huber, F., et al. (2024). An integrated proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy. Biotechnology of nature. doi.org/10.1038/s41587-024-02420-y.

cancer computational design personalized pipeline revolutionizes vaccine
bhanuprakash.cg
healthtost
  • Website

Related Posts

AI model detects brain tumors with high precision using epigenetic fingerprints

June 8, 2025

The new study warns long -term risks from germ transplants

June 8, 2025

Self-collection tests could be a solution to increase access to cervical cancer control

June 7, 2025

Leave A Reply Cancel Reply

Don't Miss
Men's Health

30 minutes Kettlebell Core Workouts to strengthen your abdomen

By healthtostJune 9, 20250

Looking to get your basic training at the next level in just 30 minutes? A…

Semaglutide for Weight Loss – Summer Safety and Side Effects Guide

June 9, 2025

Teenagers and sexual education during the Covid-19 pandemic and beyond

June 9, 2025

Creamy all the toast Avocado bagel (easy, salty breakfast!)

June 8, 2025
Stay In Touch
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
TAGS
Baby benefits body brain cancer care Day Diet disease exercise finds Fitness food Guide health healthy heart Life Loss Men mental Natural Nutrition Patients Pregnancy protein research reveals Review risk routine sex sexual Skin study Therapy Tips Top Training Treatment Understanding ways weight women Workout
About Us
About Us

Welcome to HealthTost, your trusted source for breaking health news, expert insights, and wellness inspiration. At HealthTost, we are committed to delivering accurate, timely, and empowering information to help you make informed decisions about your health and well-being.

Latest Articles

30 minutes Kettlebell Core Workouts to strengthen your abdomen

June 9, 2025

Semaglutide for Weight Loss – Summer Safety and Side Effects Guide

June 9, 2025

Teenagers and sexual education during the Covid-19 pandemic and beyond

June 9, 2025
New Comments
    Facebook X (Twitter) Instagram Pinterest
    • About Us
    • Contact Us
    • Privacy Policy
    • Terms and Conditions
    • Disclaimer
    © 2025 HealthTost. All Rights Reserved.

    Type above and press Enter to search. Press Esc to cancel.